Applied Microbiology and Biotechnology

, Volume 102, Issue 15, pp 6279–6298 | Cite as

Production of bioproducts by endophytic fungi: chemical ecology, biotechnological applications, bottlenecks, and solutions

  • Lu Yan
  • Haobin Zhao
  • Xixi Zhao
  • Xiaoguang Xu
  • Yichao Di
  • Chunmei Jiang
  • Junling ShiEmail author
  • Dongyan Shao
  • Qingsheng Huang
  • Hui Yang
  • Mingliang Jin


Endophytes are microorganisms that colonize the interior of host plants without causing apparent disease. They have been widely studied for their ability to modulate relationships between plants and biotic/abiotic stresses, often producing valuable secondary metabolites that can affect host physiology. Owing to the advantages of microbial fermentation over plant/cell cultivation and chemical synthesis, endophytic fungi have received significant attention as a mean for secondary metabolite production. This article summarizes currently reported results on plant-endophyte interaction hypotheses and highlights the biotechnological applications of endophytic fungi and their metabolites in agriculture, environment, biomedicine, energy, and biocatalysts. Current bottlenecks in industrial development and commercial applications as well as possible solutions are also discussed.


Endophyte Mutualism Interaction benefit Adversity tolerance Nutrient acquisition Biocontrol Bioproduct 



This study was funded by the National Natural Science Foundation of China (grant no. 31471718, 1701722), the Modern Agricultural Industry Technology System (CARS-30), the National Key Technology R&D Program (2015BAD16B02), Key Research and Development Plan of Shaanxi Province (2017ZDXL-NY-0304), the Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University (CX201840), and the Key Projects of Graduate Creative Innovation Seed Funding of the Northwestern University of Technology (Z2017059).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Lu Yan
    • 1
  • Haobin Zhao
    • 1
  • Xixi Zhao
    • 1
  • Xiaoguang Xu
    • 1
  • Yichao Di
    • 1
  • Chunmei Jiang
    • 1
  • Junling Shi
    • 1
    Email author
  • Dongyan Shao
    • 1
  • Qingsheng Huang
    • 1
  • Hui Yang
    • 1
  • Mingliang Jin
    • 1
  1. 1.Key Laboratory for Space Bioscience and Biotechnology, School of Life SciencesNorthwestern Polytechnical UniversityXi’anChina

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