Applied Microbiology and Biotechnology

, Volume 102, Issue 8, pp 3475–3485 | Cite as

Genomic and phenotypic diversity of Listeria monocytogenes clonal complexes associated with human listeriosis

  • Teresa M. Bergholz
  • Manoj K. Shah
  • Laurel S. Burall
  • Mira Rakic-Martinez
  • Atin R. Datta
Mini-Review

Abstract

Listeria monocytogenes is a pathogen of significant concern in many ready to eat foods due to its ability to survive and multiply even under significant environmental stresses. Listeriosis in humans is a concern, especially to high-risk populations such as those who are immunocompromised or pregnant, due to the high rates of morbidity and mortality. Whole genome sequencing has become a routine part of assessing L. monocytogenes isolated from patients, and the frequency of different genetic subtypes associated with listeriosis is now being reported. The recent abundance of genome sequences for L. monocytogenes has provided a wealth of information regarding the variation in core and accessory genomic elements. Newly described accessory genomic regions have been linked to greater virulence capabilities as well as greater resistance to environmental stressors such as sanitizers commonly used in food processing facilities. This review will provide a summary of our current understanding of stress response and virulence phenotypes of L. monocytogenes, within the context of the genetic diversity of the pathogen.

Keywords

Listeria monocytogenes Listeriosis Stress response Genetic variation Adaptation 

Notes

Acknowledgements

Teresa M. Bergholz and the work in the Bergholz lab is partially supported by the National Institute of Food and Agriculture, U.S. Department of Agriculture, under project no. ND02426. Mira Rakic-Martinez was supported by the Oak Ridge Institute for Science and Education Research Participation Program to the FDA.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any experiments with human participants or animals performed by the authors.

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Copyright information

© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2018

Authors and Affiliations

  1. 1.Department of Microbiological SciencesNorth Dakota State UniversityFargoUSA
  2. 2.Center for Food Safety and Applied NutritionFood and Drug AdministrationLaurelUSA

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