Applied Microbiology and Biotechnology

, Volume 102, Issue 5, pp 2075–2089 | Cite as

Strategies to prevent the occurrence of resistance against antibiotics by using advanced materials

  • Arnau Bassegoda
  • Kristina Ivanova
  • Eva Ramon
  • Tzanko TzanovEmail author


Drug resistance occurrence is a global healthcare concern responsible for the increased morbidity and mortality in hospitals, time of hospitalisation and huge financial loss. The failure of the most antibiotics to kill “superbugs” poses the urgent need to develop innovative strategies aimed at not only controlling bacterial infection but also the spread of resistance. The prevention of pathogen host invasion by inhibiting bacterial virulence and biofilm formation, and the utilisation of bactericidal agents with different mode of action than classic antibiotics are the two most promising new alternative strategies to overcome antibiotic resistance. Based on these novel approaches, researchers are developing different advanced materials (nanoparticles, hydrogels and surface coatings) with novel antimicrobial properties. In this review, we summarise the recent advances in terms of engineered materials to prevent bacteria-resistant infections according to the antimicrobial strategies underlying their design.


Antibiotic resistance Antibiofouling Antimicrobial peptides Quorum sensing Virulence factors Nano-antimicrobial materials 


Funding information

This work was supported by the European project PROTECT—“Pre-commercial lines for production of surface nanostructured antimicrobial and anti-biofilm textiles, medical devices and water treatment membranes” (H2020 – 720851) and Spanish national project HybridNanoCoat – “Hybrid nanocoatings on indwelling medical devices with enhanced antibacterial and antibiofilm efficiency” (MAT2015-67648-R).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Arnau Bassegoda
    • 1
  • Kristina Ivanova
    • 1
  • Eva Ramon
    • 1
  • Tzanko Tzanov
    • 1
    Email author
  1. 1.Group of Molecular and Industrial Biotechnology, Department of Chemical EngineeringUniversitat Politècnica de CatalunyaTerrassaSpain

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