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Applied Microbiology and Biotechnology

, Volume 103, Issue 4, pp 1667–1680 | Cite as

Recent advancements in high-level synthesis of the promising clinical drug, prodigiosin

  • Chee-Hoo Yip
  • Orr Yarkoni
  • James Ajioka
  • Kiew-Lian Wan
  • Sheila NathanEmail author
Mini-Review
  • 634 Downloads

Abstract

Prodigiosin, a red linear tripyrrole pigment and a member of the prodiginine family, is normally secreted by the human pathogen Serratia marcescens as a secondary metabolite. Studies on prodigiosin have received renewed attention as a result of reported immunosuppressive, antimicrobial and anticancer properties. High-level synthesis of prodigiosin and the bioengineering of strains to synthesise useful prodiginine derivatives have also been a subject of investigation. To exploit the potential use of prodigiosin as a clinical drug targeting bacteria or as a dye for textiles, high-level synthesis of prodigiosin is a prerequisite. This review presents an overview on the biosynthesis of prodigiosin from its natural host Serratia marcescens and through recombinant approaches as well as highlighting the beneficial properties of prodigiosin. We also discuss the prospect of adopting a synthetic biology approach for safe and cost-effective production of prodigiosin in a more industrially compliant surrogate host.

Keywords

Prodigiosin Beneficial secondary metabolite Gene cluster Bifurcated pathway High-level synthesis 

Notes

Funding information

We gratefully acknowledge Universiti Kebangsaan Malaysia for the funding provided (grant number ICONIC-2013-004) that initiated this collaboration and the Commonwealth Scholarship Commission for supporting C.H. Yip through the Commonwealth Split-Site PhD Award 2015 during his placement at Cambridge University.

Compliance with ethical standards

Ethical statement

This article does not contain any studies with human participants or animals performed by any of the authors.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.School of Biosciences and Biotechnology, Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaBangiMalaysia
  2. 2.Department of PathologyUniversity of CambridgeCambridgeUK

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