Applied Microbiology and Biotechnology

, Volume 101, Issue 15, pp 5951–5960 | Cite as

Biological activity of lipopeptides from Bacillus

  • Haobin Zhao
  • Dongyan Shao
  • Chunmei Jiang
  • Junling ShiEmail author
  • Qi Li
  • Qingsheng Huang
  • Muhammad Shahid Riaz Rajoka
  • Hui Yang
  • Mingliang Jin


The lipopeptides of Bacillus are small metabolites that contain a cyclic structure formed by 7–10 amino acids (including 2–4 d-amino acids) and a beta-hydroxy fatty acid with 13–19 C atoms. These lipopeptides exhibit a variety of biological activities, including interactions with biofilms, and anti-fungal, anti-inflammatory, anti-tumor, anti-virus, and anti-platelet properties. The multiple activities of lipopeptides have stimulated significant interest in the exploitation of these lipopeptides for use as antibiotics, feed additives, anti-tumor agents, urgent thrombolytic therapeutic agents, and drug delivery systems. Understanding the natural function of these structurally diverse lipopeptides in Bacillus provides insight into microbial regulatory programs and is required for efficient development of more effective products. Currently, there is still insufficient knowledge of the direct target of these lipopeptides, and continued efforts are needed to enhance their biosynthesis efficiency for industrial applications.


Bacillus subtilis Lipopeptide Surfactin Iturin Fengycin 



This review was supported by the National Science-Technology Support Plan Projects (No. 2015BAD16B02), the National Natural Science Fund (Grant No. 31471718), the Agriculture Department of China (Grant No. CARS-30), and the Northwestern Polytechnical University (No. 3102014JCQ15011 and No. 3102014GEKY1010).

Author contribution

Haobin Zhao and Junling Shi were responsible for writing the review. Muhammad Shahid Riaz Rajoka assisted in revising the article. Dongyan Shao and Chunming Jiang assisted in providing references for the manuscript. Qi Li, Qinsheng Huang, Hui Yang, and Mingliang Jin did the final proofreading of the manuscript. All authors reviewed the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Haobin Zhao
    • 1
  • Dongyan Shao
    • 1
  • Chunmei Jiang
    • 1
  • Junling Shi
    • 1
    Email author
  • Qi Li
    • 1
  • Qingsheng Huang
    • 1
  • Muhammad Shahid Riaz Rajoka
    • 1
  • Hui Yang
    • 1
  • Mingliang Jin
    • 1
  1. 1.Key Laboratory for Space Bioscience and Biotechnology, School of Life SciencesNorthwestern Polytechnical UniversityXi’anChina

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