Abstract
Saccharomyces cerevisiae is a work horse for production of valuable biofuels and biochemicals including 2,3-butanediol (2,3-BDO), a platform chemical with wide industrial applications for synthetic rubber, biosolvents and food additives. Recently, a cutting-edge technology of metabolic engineering has enabled S. cerevisiae to produce 2,3-BDO with high yield and productivity. These include (i) amplification of the 2,3-BDO biosynthetic pathway, (ii) redirection of carbon flux from ethanol or glycerol toward 2,3-BDO, and (iii) 2,3-BDO production from sugars derived from renewable biomass. These breakthroughs enforced S. cerevisiae to become a promising microbial host for production of 2,3-BDO.
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This research was financially supported by the Advanced Biomass R&D Center (ABC) of Global Frontier Project (2011-0031359) funded by the Korean Ministry of Science, ICT and Future Planning and also by the R&D program of MOTIE/KEIT (10049675).
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Kim, SJ., Kim, JW., Lee, YG. et al. Metabolic engineering of Saccharomyces cerevisiae for 2,3-butanediol production. Appl Microbiol Biotechnol 101, 2241–2250 (2017). https://doi.org/10.1007/s00253-017-8172-1
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DOI: https://doi.org/10.1007/s00253-017-8172-1