Transporter and its engineering for secondary metabolites
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Secondary metabolites possess a lot of biological activities, and to achieve their functions, transmembrane transportation is crucial. Elucidation of their transport mechanisms in the cell is critical for discovering ways to improve the production. Here, we have summarized the recent progresses for representative secondary metabolite transporters and also the strategies for uncovering the transporter systems in plants and microbes. We have also discussed the transporter engineering strategies being utilized for improving the heterologous natural product production, which exhibits promising future under the guide of synthetic biology.
KeywordsSecondary metabolites Transporter Engineering Heterologous expression Synthetic biology
This work was supported by the National Basic Research Program of China (“973” Program, grant No. 2012CB721104), the National Natural Science Foundation of China (grant No. 31170101).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
This article does not contain any studies with human participants or animals performed by any of the authors.
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