Interactions between Pseudomonas aeruginosa and Staphylococcus aureus during co-cultivations and polymicrobial infections
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Pseudomonas aeruginosa and Staphylococcus aureus are versatile bacterial pathogens and common etiological agents in polymicrobial infections. Microbial communities containing both of these pathogens are shaped by interactions ranging from parasitic to mutualistic, with the net impact of these interactions in many cases resulting in enhanced virulence. Polymicrobial communities of these organisms are further defined by multiple aspects of the host environment, with important implications for disease progression and therapeutic outcomes. This mini-review highlights the impact of these interactions on the host and individual pathogens, the molecular mechanisms that underlie these interactions, and host-specific factors that drive interactions between these two important pathogens.
KeywordsPseudomonas aeruginosa Staphylococcus aureus Cystic fibrosis Polymicrobial infections Alkyl-quinolones
Compliance with ethical standards
Funding is provided by the University of Maryland School of Pharmacy (to AGO) and NIH training grant T32 GM 066706 (to ATN).
Angela T. Nguyen declares that she has no conflict of interest. Amanda G. Oglesby-Sherrouse declares that she has no conflict of interest. This article does not contain any studies with human participants or animals performed by any of the authors.
- Ahlgren HG, Benedetti A, Landry JS, Bernier J, Matouk E, Radzioch D, Lands LC, Rousseau S, Nguyen D (2015) Clinical outcomes associated with Staphylococcus aureus and Pseudomonas aeruginosa airway infections in adult cystic fibrosis patients. BMC Pulm Med 15:67CrossRefPubMedPubMedCentralGoogle Scholar
- Baldan R, Cigana C, Testa F, Bianconi I, De Simone M, Pellin D, Di Serio C, Bragonzi A, Cirillo DM (2014) Adaptation of Pseudomonas aeruginosa in cystic fibrosis airways influences virulence of Staphylococcus aureus in vitro and murine models of co-infection. PLoS One 9:e89614CrossRefPubMedPubMedCentralGoogle Scholar
- Bouvier NM (2016) Cystic fibrosis and the war for iron at the host-pathogen battlefront. Proc Natl Acad Sci 113:1480–1482. doi: 10.1073/pnas.1525101113
- Bryan LE, Van Den Elzen HM (1977) Effects of membrane-energy mutations and cations on streptomycin and gentamicin accumulation by bacteria: a model for entry of streptomycin and gentamicin in susceptible and resistant bacteria. Antimicrob Agents Chemother 12:163–177CrossRefPubMedPubMedCentralGoogle Scholar
- Deziel E, Lepine F, Milot S, He J, Mindrinos MN, Tompkins RG, Rahme LG (2004) Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication. Proc Natl Acad Sci U S A 101:1339–1344CrossRefPubMedPubMedCentralGoogle Scholar
- Diggle SP, Matthijs S, Wright VJ, Fletcher MP, Chhabra SR, Lamont IL, Kong X, Hider RC, Cornelis P, Camara M, Williams P (2007) The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment. Chem Biol 14:87–96CrossRefPubMedGoogle Scholar
- Filkins LM, Graber JA, Olson DG, Dolben EL, Lynd LR, Bhuju S, O’Toole GA (2015) Co-culture of Staphylococcus aureus with Pseudomonas aeruginosa drives S. aureus towards fermentative metabolism and reduced viability in a cystic fibrosis model. J Bacteriol 197:2252–2264. doi: 10.1128/JB.00059-15
- Foundation, Cystic Fibrosis (2014) Patient registry annual data report 2014. Cystic Fibrosis Foundation, BethesdaGoogle Scholar
- Fugere A, Lalonde Seguin D, Mitchell G, Deziel E, Dekimpe V, Cantin AM, Frost E, Malouin F (2014) Interspecific small molecule interactions between clinical isolates of Pseudomonas aeruginosa and Staphylococcus aureus from adult cystic fibrosis patients. PLoS One 9:e86705CrossRefPubMedPubMedCentralGoogle Scholar
- Hoffman LR, Deziel E, D’Argenio DA, Lepine F, Emerson J, McNamara S, Gibson RL, Ramsey BW, Miller SI (2006) Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 103:19890–19895CrossRefPubMedPubMedCentralGoogle Scholar
- Hubert D, Reglier-Poupet H, Sermet-Gaudelus I, Ferroni A, Le Bourgeois M, Burgel PR, Serreau R, Dusser D, Poyart C, Coste J (2013) Association between Staphylococcus aureus alone or combined with Pseudomonas aeruginosa and the clinical condition of patients with cystic fibrosis. J Cyst Fibros 12:497–503CrossRefPubMedGoogle Scholar
- Nguyen AT, Jones JW, Ruge MA, Kane MA, Oglesby-Sherrouse AG (2015) Iron depletion enhances production of antimicrobials by Pseudomonas aeruginosa. J Bacteriol 197:2265–2275. doi: 10.1128/JB.00072-15
- Nguyen AT, O’Neill MJ, Watts AM, Robson CL, Lamont IL, Wilks A, Oglesby-Sherrouse AG (2014) Adaptation of iron homeostasis pathways by a Pseudomonas aeruginosa pyoverdine mutant in the cystic fibrosis lung. J Bacteriol 196:2265–2276. doi: 10.1128/JB.01491-14