Biotransformations of organic compounds mediated by cultures of Aspergillus niger
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Many different organic compounds may be converted by microbial biotransformation to high-value products for the chemical and pharmaceutical industries. This review summarizes the use of strains of Aspergillus niger, a well-known filamentous fungus used in numerous biotechnological processes, for biochemical transformations of organic compounds. The substrates transformed include monocyclic, bicyclic, and polycyclic aromatic hydrocarbons; azaarenes, epoxides, chlorinated hydrocarbons, and other aliphatic and aromatic compounds. The types of reactions performed by A. niger, although not unique to this species, are extremely diverse. They include hydroxylation, oxidation of various functional groups, reduction of double bonds, demethylation, sulfation, epoxide hydrolysis, dechlorination, ring cleavage, and conjugation. Some of the products may be useful as new investigational drugs or chemical intermediates.
KeywordsArenes Aspergillus niger Biotransformation Hydrocarbons Organic compounds
The authors would like to thank Dr. C. E. Cerniglia, Dr. F. A. Beland, Dr. L. Loukotková, and Dr. B. D. Erickson for their helpful comments on the manuscript. The views presented in this article do not necessarily reflect those of the US Food and Drug Administration.
Conflict of interest
The authors declare that they have no competing interests.
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