Applied Microbiology and Biotechnology

, Volume 97, Issue 4, pp 1407–1424 | Cite as

Microbial production of poly(hydroxybutyrate) from C1 carbon sources

  • Kianoush Khosravi-DaraniEmail author
  • Zahra-Beigom Mokhtari
  • Tomohito Amai
  • Kenji Tanaka


Polyhydroxybutyrate (PHB) is an attractive substitute for petrochemical plastic due to its similar properties, biocompatibility, and biodegradability. The cost of scaled-up PHB production inhibits its widespread usage. Intensive researches are growing to reduce costs and improve thermomechanical, physical, and processing properties of this green biopolymer. Among cheap substrates which are used for reducing total cost of PHB production, some C1 carbon sources, e.g., methane, methanol, and CO2 have received a great deal of attention due to their serious role in greenhouse problem. This article reviews the fundamentals of strategies for reducing PHA production and moves on to the applications of several cheap substrates with a special emphasis on methane, methanol, and CO2. Also, some explanation for involved microorganisms including the hydrogen-oxidizing bacteria and methanotrophs, their history, culture condition, and nutritional requirements are given. After description of some important strains among the hydrogen-oxidizing and methanotrophic producers of PHB, the article is focused on limitations, threats, and opportunities for application and their future trends.


Polyhydroxybutyrate C1 carbon sources Methanol Methane CO2 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Kianoush Khosravi-Darani
    • 1
    Email author
  • Zahra-Beigom Mokhtari
    • 2
  • Tomohito Amai
    • 3
  • Kenji Tanaka
    • 3
  1. 1.Department of Food Technology Research, National Nutrition and Food Technology Research InstituteFaculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical ScienceTehranIran
  2. 2.Department of Chemical Engineering, School of Petroleum and Petrochemical EngineeringHakim Sabzevari UniversitySabzevarIran
  3. 3.Department of Biological and Environmental ChemistryFaculty of Humanity-Oriented Science and Engineering, Kinki UniversityIizuka-siJapan

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