Applied Microbiology and Biotechnology

, Volume 91, Issue 4, pp 937–947 | Cite as

Scleroglucan: biosynthesis, production and application of a versatile hydrocolloid

  • Jochen Schmid
  • Vera Meyer
  • Volker Sieber


Since its first description in the early 1960s, scleroglucan attracted much attention from both academia and industry. Scleroglucan is an exopolysaccharide secreted by the basidiomycete Sclerotium rolfsii and appreciated as a multipurpose compound applicable in many industrial fields, including oil industry, food industry and pharmacy. In this review, the current knowledge on scleroglucan chemistry, genetics, biosynthesis and production will be summarized and different application possibilities will be discussed. The biosynthesis of scleroglucan in S. rolfsii will be highlighted by recent transcriptomic data and linked to physiological data to better understand the biogenesis of scleroglucan and its link to the phytopathologic lifestyle of S. rolfsii.


Scleroglucan Biosynthesis Sclerotium rolfsii Fermentation Transcriptome Exopolysaccharide 



This work was supported in part by the German Federal Ministry of Research and Education for financial support (BMBF grant 0313397). The authors are grateful to Brian McNeal and Robert Seviour for exchange of unpublished documents.


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© Springer-Verlag 2011

Authors and Affiliations

  1. 1.Institute of Chemistry of Biogenic ResourcesTechnische Universität MünchenStraubingGermany
  2. 2.Department of Applied and Molecular MicrobiologyBerlin University of TechnologyBerlinGermany

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