Applied Microbiology and Biotechnology

, Volume 90, Issue 5, pp 1589–1608 | Cite as

Overcoming substrate inhibition during biological treatment of monoaromatics: recent advances in bioprocess design

  • Andrew J. DaugulisEmail author
  • M. Concetta Tomei
  • Benoit Guieysse


The biological removal of monoaromatic compounds from contaminated environments, usually arising from industrial activity, is challenging because of the inherent toxicity of these compounds to microorganisms, particularly at the concentrations that can be encountered in industrial waste streams. A wide range of bioprocess designs have been proposed and tested with the aim of achieving high removal efficiencies, with varying degrees of technical success, and potential for practical implementation. This review reports on the progress on variations of well-known themes made in the last 3–4 years, as well as new bioprocess technologies that address the cytotoxicity of monoaromatics directly. Areas for further research are also proposed.


Monoaromatics Bioprocess designs Cytotoxicity 



AJD is grateful to Timothy Simon for helpful discussions.


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Andrew J. Daugulis
    • 1
    Email author
  • M. Concetta Tomei
    • 2
  • Benoit Guieysse
    • 3
  1. 1.Department of Chemical EngineeringQueen’s UniversityKingstonCanada
  2. 2.Water Research Institute, C.N.RRomeItaly
  3. 3.School of Engineering & Advanced TechnologyMassey UniversityPalmerston NorthNew Zealand

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