Applied Microbiology and Biotechnology

, Volume 87, Issue 4, pp 1281–1289 | Cite as

Biotechnological production and applications of N-acetyl-d-neuraminic acid: current state and perspectives

Mini-Review

Abstract

N-Acetyl-d-neuraminic acid (Neu5Ac) and its derivates are a very important group of biomolecules because these sugars occupy the terminal positions in numerous macromolecules, such as the glycans of glycoproteins, and are involved in many biological and pathological phenomena. The synthesis and applications of Neu5Ac are attracting much interest due to the potential applications of this compound in the pharmaceutical industry, such as in the synthesis of the anti-flu drug zanamivir. In this review article, we discuss existing knowledge on the biotechnological production and applications of Neu5Ac and also propose some guidelines for future studies.

Keywords

N-Acetyl-d-neuraminic acid Sialic acid Biocatalysis Application 

Notes

Acknowledgements

The study was partly supported by grants from the State Major Basic Research Development Program (China; Numbers: 2007CB714303 and 2007CB707803). The authors would also like to acknowledge partial financial support from National Natural Science Foundation of China.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.MOE Key Laboratory of Microbial Metabolism and School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiPeople’s Republic of China
  2. 2.State Key Laboratory of Microbial TechnologyShandong UniversityJinanPeople’s Republic of China

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