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Applied Microbiology and Biotechnology

, Volume 86, Issue 6, pp 1707–1717 | Cite as

A review: recent advances and future prospects of taxol-producing endophytic fungi

  • Xuanwei Zhou
  • Huifang Zhu
  • Lu Liu
  • Juan Lin
  • Kexuan Tang
Mini-Review

Abstract

In the urgent search for more effective ways to treat cancer, new extraction methods of taxol from endophytic fungus have demonstrated high potential in increasing the efficiency of taxol extraction for more efficient and sustainable production of taxol and cancer treatment products. This paper summarizes recent advances in taxol-producing endophytic fungi, both in China and abroad, in the following areas: isolation and identification of endophytic fungi types, extraction and detection methods of endophytic taxol in plants, and improved efficiency of the extraction process. With the advancement of science and technology, new techniques in biotechnology, such as fungal strain improvement and recombining technique and microbial fermentation engineering, have increased the extraction yield from taxol-producing fungi, thereby improved the overall efficiency of taxol production.

Keywords

Taxol Endophytic fungi Isolation Identification Meliorate 

Notes

Acknowledgments

We would like to thank Dr. Xiaojun Liu for his help in smoothing out the whole manuscript. This research is financially supported by the China National “863” High-Tech Program (project No. 2007AA021501), the Shanghai Science and Technology Committee (project No. 07DZ19724), and the Shanghai Leading Academic Discipline Project (project No. B209).

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Xuanwei Zhou
    • 1
  • Huifang Zhu
    • 1
  • Lu Liu
    • 2
  • Juan Lin
    • 2
  • Kexuan Tang
    • 1
  1. 1.Plant Biotechnology Research Center, School of Agriculture and Biology, Fudan–SJTU–Nottingham Plant Biotechnology R&D CenterShanghai Jiao Tong UniversityShanghaiPeople’s Republic of China
  2. 2.State Key Laboratory of Genetic Engineering, School of Life Sciences, Morgan–Tan International Center for Life Sciences, Fudan–SJTU–Nottingham Plant Biotechnology R&D CenterFudan UniversityShanghaiPeople’s Republic of China

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