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Applied Microbiology and Biotechnology

, Volume 86, Issue 5, pp 1313–1322 | Cite as

Carbohydrate metabolism in Corynebacterium glutamicum and applications for the metabolic engineering of l-lysine production strains

  • Bastian Blombach
  • Gerd M. SeiboldEmail author
Mini-Review

Abstract

Carbohydrates exclusively serve as feedstock for industrial amino acid production with Corynebacterium glutamicum. Due to the industrial interest, knowledge about the pathways for carbohydrate metabolization in C. glutamicum steadily increases, enabling the rational design of optimized strains and production processes. In this review, we provide an overview of the metabolic pathways for utilization of hexoses (glucose, fructose), disaccharides (sucrose, maltose), pentoses (d-ribose, l-arabinose, d-xylose), gluconate, and β-glucosides present in C. glutamicum. Recent approaches of metabolic engineering of l-lysine production strains based on the known pathways are described and evaluated with respect to l-lysine yields.

Keywords

Corynebacterium glutamicum Carbohydrates Sugar Metabolic engineering Amino acid production l-Lysine 

Notes

Acknowledgment

We thank B. J. Eikmanns for valuable discussions and for critically reading this manuscript.

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© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Institute of Microbiology and BiotechnologyUniversity of UlmUlmGermany
  2. 2.Institute of BiochemistryUniversity of CologneCologneGermany

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