Applied Microbiology and Biotechnology

, Volume 86, Issue 6, pp 1719–1736 | Cite as

Unraveling polyketide synthesis in members of the genus Aspergillus

  • Yi-Ming Chiang
  • Berl R. Oakley
  • Nancy P. Keller
  • Clay C. C. Wang


Aspergillus species have the ability to produce a wide range of secondary metabolites including polyketides that are generated by multi-domain polyketide synthases (PKSs). Recent biochemical studies using dissected single or multiple domains from PKSs have provided deep insight into how these PKSs control the structural outcome. Moreover, the recent genome sequencing of several species has greatly facilitated the understanding of the biosynthetic pathways for these secondary metabolites. In this review, we will highlight the current knowledge regarding polyketide biosynthesis in Aspergillus based on the domain architecture of non-reducing, highly reducing, and partially reducing PKSs, and PKS-non-ribosomal peptide synthetases.


Secondary metabolites Fungi Polyketide Nonribosomal peptides 


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Yi-Ming Chiang
    • 1
    • 2
  • Berl R. Oakley
    • 3
  • Nancy P. Keller
    • 4
    • 5
  • Clay C. C. Wang
    • 2
    • 6
  1. 1.Graduate Institute of Pharmaceutical ScienceChia Nan University of Pharmacy and ScienceTainanRepublic of China
  2. 2.Department of Pharmacology and Pharmaceutical SciencesUniversity of Southern California, School of PharmacyLos AngelesUSA
  3. 3.Department of Molecular BiosciencesUniversity of KansasLawrenceUSA
  4. 4.Department of Medical Microbiology and ImmunologyUniversity of Wisconsin-MadisonMadisonUSA
  5. 5.Department of BacteriologyUniversity of Wisconsin-MadisonMadisonUSA
  6. 6.Department of ChemistryUniversity of Southern California, College of Letters, Arts, and SciencesLos AngelesUSA

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