Applied Microbiology and Biotechnology

, Volume 85, Issue 5, pp 1339–1351 | Cite as

Bench to batch: advances in plant cell culture for producing useful products

  • Pamela J. Weathers
  • Melissa J. Towler
  • Jianfeng Xu


Despite significant efforts over nearly 30 years, only a few products produced by in vitro plant cultures have been commercialized. Some new advances in culture methods and metabolic biochemistry have improved the useful potential of plant cell cultures. This review will provide references to recent relevant reviews along with a critical analysis of the latest improvements in plant cell culture, co-cultures, and disposable reactors for production of small secondary product molecules, transgenic proteins, and other products. Some case studies for specific products or production systems are used to illustrate principles.


Bioreactor Secondary metabolism Co-cultures Disposable reactors 



Support was provided in part by the Arkansas Biosciences Institute, the major research component of the Arkansas Tobacco Settlement Proceeds Act of 2000.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Pamela J. Weathers
    • 1
  • Melissa J. Towler
    • 1
  • Jianfeng Xu
    • 2
  1. 1.Department of Biology and Biotechnology at GatewayWorcester Polytechnic InstituteWorcesterUSA
  2. 2.Arkansas Bioscience Institutealso College of Agriculture, Arkansas State UniversityJonesboroUSA

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