Applied Microbiology and Biotechnology

, Volume 84, Issue 1, pp 55–62 | Cite as

Recent advances in the biological production of mannitol

  • Seung Hoon Song
  • Claire Vieille


Mannitol is a fructose-derived, 6-carbon sugar alcohol that is widely found in bacteria, yeasts, fungi, and plants. Because of its desirable properties, mannitol has many applications in pharmaceutical products, in the food industry, and in medicine. The current mannitol chemical manufacturing process yields crystalline mannitol in yields below 20 mol% from 50% glucose/50% fructose syrups. Thus, microbial and enzymatic mannitol manufacturing methods have been actively investigated, in particular in the last 10 years. This review summarizes the most recent advances in biological mannitol production, including the development of bacterial-, yeast-, and enzyme-based transformations.


Mannitol Fructose Lactic acid bacteria Mannitol biological production Cofactor regeneration Glucose 



This work was supported by the National Research Initiative grant number 2008-35504-04611 from the United States Department of Agriculture’s Cooperative State Research, Education, and Extension Service.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of Microbiology & Molecular Genetics, 2215 Biomedical Physical Sciences BuildingMichigan State UniversityEast LansingUSA
  2. 2.Department of Biochemistry & Molecular BiologyMichigan State UniversityEast LansingUSA

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