Applied Microbiology and Biotechnology

, Volume 78, Issue 1, pp 17–28 | Cite as

A small protein that fights fungi: AFP as a new promising antifungal agent of biotechnological value

Mini-Review

Abstract

As fungal infections are becoming more prevalent in the medical or agricultural fields, novel and more efficient antifungal agents are badly needed. Within the scope of developing new strategies for the management of fungal infections, antifungal compounds that target essential fungal cell wall components are highly preferable. Ideally, newly developed antimycotics should also combine major aspects such as sustainability, high efficacy, limited toxicity and low costs of production. A naturally derived molecule that possesses all the desired characteristics is the antifungal protein (AFP) secreted by the filamentous ascomycete Aspergillus giganteus. AFP is a small, basic and cysteine-rich peptide that exerts extremely potent antifungal activity against human- and plant-pathogenic fungi without affecting the viability of bacteria, yeast, plant and mammalian cells. This review summarises the current knowledge of the structure, mode of action and expression of AFP, and highlights similarities and differences concerning these issues between AFP and its related proteins from other Ascomycetes. Furthermore, the potential use of AFP in the combat against fungal contaminations and infections will be discussed.

Keywords

Antifungal protein Aspergillus giganteus Pathogenic fungi Cell wall integrity Chitin biosynthesis Antifungal treatment 

Notes

Acknowledgment

The author would like to thank the Arbeitsgemeinschaft industrieller Forschungsvereinigungen “Otto von Guericke” for the financial support, and Silke Hagen and Anja Spielvogel for sharing unpublished data.

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© Springer-Verlag 2007

Authors and Affiliations

  1. 1.TU Berlin, Institut für Biotechnologie, Fachgebiet Mikrobiologie und GenetikBerlinGermany

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