Applied Microbiology and Biotechnology

, Volume 76, Issue 4, pp 727–740 | Cite as

Prospects for a bio-based succinate industry

  • James B. McKinlay
  • C. Vieille
  • J. Gregory ZeikusEmail author


Bio-based succinate is receiving increasing attention as a potential intermediary feedstock for replacing a large petrochemical-based bulk chemical market. The prospective economical and environmental benefits of a bio-based succinate industry have motivated research and development of succinate-producing organisms. Bio-based succinate is still faced with the challenge of becoming cost competitive against petrochemical-based alternatives. High succinate concentrations must be produced at high rates, with little or no by-products to most efficiently use substrates and to simplify purification procedures. Herein are described the current prospects for a bio-based succinate industry, with emphasis on specific bacteria that show the greatest promise for industrial succinate production. The succinate-producing characteristics and the metabolic pathway used by each bacterial species are described, and the advantages and disadvantages of each bacterial system are discussed.


Bio-based succinate 1,4-Butanediol Metabolic engineering Escherichia coli Actinobacillus succinogenes Mannheimia succiniciproducens 



We gratefully acknowledge Drs. Michael Bagdasarian, John Breznak, John Ohlrogge, C. Adinarayana Reddy, and Yair Shachar-Hill for valuable discussions.


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • James B. McKinlay
    • 1
  • C. Vieille
    • 2
  • J. Gregory Zeikus
    • 1
    • 2
    Email author
  1. 1.Department of Microbiology and Molecular GeneticsMichigan State UniversityEast LansingUSA
  2. 2.Department of Biochemistry and Molecular BiologyMichigan State UniversityEast LansingUSA

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