Applied Microbiology and Biotechnology

, Volume 75, Issue 3, pp 487–497

Histone deacetylases—an important class of cellular regulators with a variety of functions

  • Christian Hildmann
  • Daniel Riester
  • Andreas Schwienhorst
Mini-Review

DOI: 10.1007/s00253-007-0911-2

Cite this article as:
Hildmann, C., Riester, D. & Schwienhorst, A. Appl Microbiol Biotechnol (2007) 75: 487. doi:10.1007/s00253-007-0911-2

Abstract

The elucidation of mechanisms of chromatin remodeling, particular transcriptional activation, and repression by histone acetylation and deacetylation has shed light on the role of histone deacetylases (HDAC) as a new kind of therapeutic target for human cancer treatment. HDACs, in general, act as components of large corepressor complexes that prevent the transcription of several tumor suppression genes. In addition, they appear to be also involved in the deacetylation of nonhistone proteins. This paper reviews the most recent insights into the diverse biological roles of HDACs as well as the evolution of this important protein family.

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Christian Hildmann
    • 1
  • Daniel Riester
    • 1
  • Andreas Schwienhorst
    • 1
  1. 1.Department of Molecular Genetics and Preparative Molecular BiologyInstitute for Microbiology and GeneticsGöttingenGermany

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