Applied Microbiology and Biotechnology

, Volume 72, Issue 6, pp 1152–1156 | Cite as

Hypoglycemic activity of the fungi Cordyceps militaris, Cordyceps sinensis, Tricholoma mongolicum, and Omphalia lapidescens in streptozotocin-induced diabetic rats

  • Guoqing Zhang
  • Yuedong Huang
  • Yong Bian
  • Jack H. Wong
  • T. B. Ng
  • Hexiang WangEmail author
Biotechnological Products and Process Engineering


Crude extracts were prepared from fruiting bodies and mycelia of the medicinal fungus Cordyceps militaris, and a polysaccharide-enriched fraction was obtained after extraction with hot water and ethanol precipitation. Polysaccharide-enriched fractions were similarly prepared from Cordyceps sinensis, Omphalia lapidescens, and Tricholoma mongolicum. The various aforementioned preparations were orally administered into different groups of adult rats 24 h before an intraperitoneal injection of streptozotocin (40 mg/kg body weight), and subsequently daily for another 4 days. The dosage used was 10 mg/kg body weight for polysaccharide-enriched preparations and 100 mg/kg body weight for crude extracts. Control rats received distilled water instead of crude extract or polysaccharide-enriched preparation. It was found in the control rats that plasma glucose level rose from about 90 mg/dl before streptozotocin injection to levels that were maintained at about 300 mg/dl postinjection. All preparations produced hypoglycemic effects. C. militaris polysaccharide-enriched fraction displayed a more prominent effect than that of C. sinensis polysaccharide-enriched fraction which in turn was more potent than that of O. lapidescens and T. mongolicum polysaccharide-enriched fractions. The hypoglycemic effect of C. militaris polysaccharide-enriched fraction was dose-dependent.


Fruiting Body Streptozotocin Hypoglycemic Effect Cordycepin Hypoglycemic Activity 
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We thank Miss Fion Yung for her expert secretarial assistance.


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Guoqing Zhang
    • 1
  • Yuedong Huang
    • 1
  • Yong Bian
    • 1
  • Jack H. Wong
    • 2
  • T. B. Ng
    • 2
  • Hexiang Wang
    • 1
    Email author
  1. 1.State Key Laboratory for Agrobiotechnology and Department of MicrobiologyChina Agricultural UniversityBeijing 100094People’s Republic of China
  2. 2.Department of Biochemistry, Faculty of MedicineThe Chinese University of Hong KongShatinPeople’s Republic of China

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