Applied Microbiology and Biotechnology

, Volume 65, Issue 3, pp 250–258 | Cite as

Strategies for bioremediation of polychlorinated biphenyls

  • Yoshiyuki OhtsuboEmail author
  • Toshiaki Kudo
  • Masataka Tsuda
  • Yuji Nagata


Polychlorinated biphenyls (PCBs) are serious environmental pollutants that threaten both the natural ecosystem and human health. For remediation of environments contaminated with PCBs, several approaches that exploit the potential of microbes to degrade PCBs have been developed. These approaches include improvement of PCB solubilization and entry into the cell, pathway and enzyme engineering, and control of enzyme expression. In this mini-review, we briefly summarize these strategies and provide potentially useful knowledge for the further improvement of the bacterial breakdown of PCBs.


PCBs Dehalogenase Degradation Gene Biphenyl Dioxygenase Biphenyl Degradation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology and the Ministry of Agriculture, Forestry, and Fisheries (HC-04-2323-1), Japan. Part of this work was performed in the Eco Molecular Science Research Program of RIKEN. Y.O. was financially supported by research fellowships from the Japan Society for the Promotion of Science for Young Scientists. Y.O. was also a special postdoctoral researcher at RIKEN.


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Yoshiyuki Ohtsubo
    • 1
    Email author
  • Toshiaki Kudo
    • 2
  • Masataka Tsuda
    • 1
  • Yuji Nagata
    • 1
  1. 1.Department of Environmental Life Sciences, Graduate School of Life SciencesTohoku UniversitySendaiJapan
  2. 2.Environmental Molecular Biology LaboratoryRIKENSaitamaJapan

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