Applied Microbiology and Biotechnology

, Volume 62, Issue 2–3, pp 99–109 | Cite as

The Corynebacterium glutamicum genome: features and impacts on biotechnological processes

  • M. IkedaEmail author
  • S. Nakagawa


Corynebacterium glutamicum has played a principal role in the progress of the amino acid fermentation industry. The complete genome sequence of the representative wild-type strain of C. glutamicum, ATCC 13032, has been determined and analyzed to improve our understanding of the molecular biology and physiology of this organism, and to advance the development of more efficient production strains. Genome annotation has helped in elucidation of the gene repertoire defining a desired pathway, which is accelerating pathway engineering. Post genome technologies such as DNA arrays and proteomics are currently undergoing rapid development in C. glutamicum. Such progress has already exposed new regulatory networks and functions that had so far been unidentified in this microbe. The next goal of these studies is to integrate the fruits of genomics into strain development technology. A novel methodology that merges genomics with classical strain improvement has been developed and applied for the reconstruction of classically derived production strains. How can traditional fermentation benefit from the C. glutamicum genomic data? The path from genomics to biotechnological processes is presented.


Bacterial Artificial Chromosome Corynebacterium Glutamicum Muffler Central Carbon Metabolism Amino Acid Production 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We would like to acknowledge all our co-workers, especially T. Nakano, S. Mitsuhashi, J. Ohnishi, H. Mizoguchi, M. Hayashi, M. Maeda, H. Sakai, K. Tanaka, N. Shiraishi, T. Ota, S. Ando, K. Ochiai, and H. Yokoi. We also thank Drs. S. Teshiba, A. Ozaki, and H. Anazawa for encouraging support of our research, and Y. Yonetani, S. Hashimoto, M. Yagasaki, and S. Koizumi for useful discussions and cooperation.


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© Springer-Verlag 2003

Authors and Affiliations

  1. 1.Tokyo Research LaboratoriesKyowa Hakko KogyoTokyoJapan
  2. 2.XanagenKanagawaJapan

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