Applied Microbiology and Biotechnology

, Volume 61, Issue 2, pp 83–93 | Cite as

Molecular genetic analysis and regulation of aflatoxin biosynthesis

  • D. BhatnagarEmail author
  • K. C. Ehrlich
  • T. E. Cleveland


Aflatoxins, produced by some Aspergillus species, are toxic and extremely carcinogenic furanocoumarins. Recent investigations of the molecular mechanism of AFB biosynthesis showed that the genes required for biosynthesis are in a 70 kb gene cluster. They encode a DNA-binding protein functioning in aflatoxin pathway gene regulation, and other enzymes such as cytochrome P450-type monooxygenases, dehydrogenases, methyltransferases, and polyketide and fatty acid synthases. Information gained from these studies has led to a better understanding of aflatoxin biosynthesis by these fungi. The characterization of genes involved in aflatoxin formation affords the opportunity to examine the mechanism of molecular regulation of the aflatoxin biosynthetic pathway, particularly during the interaction between aflatoxin-producing fungi and plants.


Aflatoxin Carbon Catabolite Repression Aflatoxin Production Alternariol Aflatoxin Biosynthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • D. Bhatnagar
    • 1
    Email author
  • K. C. Ehrlich
    • 1
  • T. E. Cleveland
    • 1
  1. 1.Southern Regional Research Center, ARSUSDANew OrleansUSA

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