Immunogenetics

, Volume 53, Issue 8, pp 669–673 | Cite as

Dog MHC alleles containing the human RA shared epitope confer susceptibility to canine rheumatoid arthritis

  • William E. Ollier
  • Lorna J. Kennedy
  • Wendy Thomson
  • Annette N. Barnes
  • Susan C. Bell
  • David Bennett
  • John M. Angles
  • John F. Innes
  • Stuart D. Carter
Original Paper

Abstract.

To determine whether canine rheumatoid arthritis (CRA) is associated with dog MHC (DLA-DRB1) alleles which contain the QRRAA/RKRAA conserved third hypervariable region (3HVR) sequence, DNA samples were extracted from 61 dogs with clinically diagnosed small-joint polyarthritis and from 425 controls. Breed-matched controls were available for 41 cases. DLA-DRB1 genotypes were identified using molecular typing methods. Phenotype frequencies were compared between cases and controls and odds ratios with 95% confidence intervals calculated. Several DLA-DRB1 alleles were associated with increased risk for CRA: DLA-DRB1*002, DRB1*009, and DRB1*018. This was also observed for the presence of any shared epitope (SE)-bearing allele. The associations with DLA-DRB1*002 and the SE were maintained when only breed-matched cases and controls were compared. This study suggests that a conserved amino acid motif in the 3HVR present in some DRB1 alleles of both dogs and humans is associated with rheumatoid arthritis in both species.

DLA-DRB1 Dog MHC Rheumatoid arthritis Shared epitope 

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • William E. Ollier
    • 1
  • Lorna J. Kennedy
    • 1
  • Wendy Thomson
    • 1
  • Annette N. Barnes
    • 1
  • Susan C. Bell
    • 1
  • David Bennett
    • 2
  • John M. Angles
    • 3
  • John F. Innes
    • 1
  • Stuart D. Carter
    • 1
  1. 1.Mammalian Immunogenetics Research Group, Faculty of Veterinary Medicine, University of Liverpool, L69 3BX, UK
  2. 2.Faculty of Veterinary Science, University of Glasgow, UK
  3. 3.Faculty of Veterinary Medicine, University College, Dublin, Ireland

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