, Volume 53, Issue 7, pp 520–542

The major histocompatibility complex of the rat (Rattus norvegicus)


DOI: 10.1007/s002510100361

Cite this article as:
Günther, E. & Walter, L. Immunogenetics (2001) 53: 520. doi:10.1007/s002510100361


This review of the RT1 complex, the major histocompatibility complex (MHC) of the rat, focuses on genetic, genomic, evolutionary, and functional aspects at the molecular level. The class I, class II, and framework genes are listed. The physical map of the RT1 complex as revealed by analysis of clonal contigs is compared with the human and mouse MHC, and the degree of orthologous relationship is outlined. Elucidation of the RT1 complex provides important information for using the rat as a model of experimental transplantation and complex diseases.

MHC Rat Evolution Disease models Transplantation 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  1. 1.Abteilung Immungenetik, Universität GöttingenGöttingenGermany

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