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Immunogenetics

, Volume 53, Issue 2, pp 95–104 | Cite as

Molecular polymorphism of O alleles in five populations of different ethnic origins

  • Francis Roubinet
  • Nathalie Kermarrec
  • Stéphanie Despiau
  • Pol-Andre Apoil
  • Jean Michel Dugoujon
  • Antoine Blancher
Original Paper

Abstract.

Sequences of exons 6 and 7 of the O allele of the ABO gene were studied in 317 individuals of the O phenotype from five different ethnic groups (Basques, Berbers, Akans from the Ivory Coast, and Amerindians: Cayapas from Ecuador and Aymaras from Bolivia). Twenty-one O alleles were characterized, among which 9 differed from all O alleles reported to date. The nine alleles differed from either the O01 allele (four out of nine) or O02 allele (five out of nine) by one to three point mutations. The number of different O alleles in population samples varied greatly: the highest number (13) was observed in Akans, and the lowest (5) in Amerindians. Some rare alleles previously reported by others at low frequencies were found with high frequencies in the Akans. The results also revealed a decreasing frequency of O v7 alleles from south to north (Akans, Berbers, Basques). Berbers and Basques share two rare alleles, O v6 and O03, which were not encountered in the other populations studied here.

ABO Blood group system Glycosyltransferase Null allele Human diversity 

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Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Francis Roubinet
    • 2
  • Nathalie Kermarrec
    • 2
  • Stéphanie Despiau
    • 1
  • Pol-Andre Apoil
    • 1
  • Jean Michel Dugoujon
    • 3
  • Antoine Blancher
    • 1
  1. 1.Laboratoire d'Immunogénétique Moléculaire, Université Paul Sabatier, Hôpital Purpan, 1, Place du Docteur Baylac, 31059, Toulouse Cedex, France
  2. 2.Laboratoire d'immunohématologie, Etablissement Français du Sang Pyrénées-Méditerranée, Avenue de Grande Bretagne, BP3210, 31027 Toulouse, France
  3. 3.Centre d'Anthropologie, UMR 8555, 37–39 allées Jules Guesde, 31000 Toulouse, France

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