Immunogenetics

, Volume 51, Issue 4, pp 373–382

BTL-II : a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse

  • M. Stammers
  • L. Rowen
  • D. Rhodes
  • J. Trowsdale
  • S. Beck
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DOI: 10.1007/s002510050633

Cite this article as:
Stammers, M., Rowen, L., Rhodes, D. et al. Immunogenetics (2000) 51: 373. doi:10.1007/s002510050633

Abstract

 Comparison of human and mouse genomic sequence at the border of the major histocompatibility complex (MHC) class II and class III regions revealed a locus encoding six exons with homology to the butyrophilin gene family and the location of a previously decribed gene, testis-specific basic protein (TSBP). We named the new locus BTL-II, for butyrophilin-like MHC class II associated. The six discernable exons of the BTL-II locus encode a small hydrophobic amino acid sequence (which may be a signal peptide), two immunoglobulin domains, a small 7-amino acid, heptad repeat-like exon, and a further two immunoglobulin domains. In mouse, an additional butyrophilin-like gene (NG10) is situated adjacent to BTL-II. Expression studies of the BTL-II locus in mouse showed that it is expressed in a range of gut tissues. We demonstrate that like many other genes from the MHC, BTL-II is polymorphic in a selection of diverse HLA haplotypes. In the light of the newly discovered locus, we revisit and discuss the possible origin of the butyrophilin gene family

Key words Butyrophilin Immunoglobulin superfamily Polymorphism MHC Testis-specific basic protein 

Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • M. Stammers
    • 1
  • L. Rowen
    • 2
  • D. Rhodes
    • 3
  • J. Trowsdale
    • 3
  • S. Beck
    • 1
  1. 1.Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK e-mail: beck@sanger.ac.uk Tel.: +44-1223-494952 Fax: +44-1223-494919GB
  2. 2.Department of Molecular Biotechnology, University of Washington, Seattle, WA 98195-7730, USAUS
  3. 3.Immunology, Department of Pathology, Tennis Court Road, Cambridge, CB2 1PQ, UKGB

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