Immunogenetics

, Volume 49, Issue 10, pp 879–885

Evidence for an additional cattle DQB locus

  • A. Gelhaus
  • Birgit Förster
  • Rolf D. Horstmann
ORIGINAL PAPER

Abstract

 Studying the genetic polymorphism of the major histocompatibility complex class II genes in cattle, we identified a sequence (KUH1) which resembles those encoding class II β chains. The gene was shown to be transcribed in peripheral blood leukocytes. Sequence comparisons, Southern blot, and phylogenetic analyses indicate that (1) KUH1 represents a distinct DQB locus, which we propose to designate BoLA-DQB5, (2) DQB5 constitutes an ancient DQB locus which diverged from a common ancestor gene prior to the duplication resulting in DQB1 and DQB2, (3) DQB5 is associated with haplotypes which contain DQA5 and a duplicated DQ region.

Key words MHC Cattle DQB BoLA-DQB5 Haplotype 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • A. Gelhaus
    • 1
  • Birgit Förster
    • 1
  • Rolf D. Horstmann
    • 1
  1. 1.Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359 Hamburg, Germany e-mail: gelhaus@bni.uni-hamburg.de, Tel.: +49-40-42818534, Fax: +49-40-42818512DE

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