Immunogenetics

, Volume 48, Issue 3, pp 222–232 | Cite as

IgG receptor polymorphisms: risk factors for disease

  • W.-Ludo van der Pol
  • J. G. J. van de Winkel
REVIEW

Abstract

 Two groups of receptors for immunoglobulin G (FcγR) can be distinguished. Endothelial cells and placental syncytiotrophoblasts express an MHC class I-like FcγR important for regulation of IgG half-life and IgG transport, respectively. FcγR expressed on leukocytes constitute a heterogeneous family of membrane bound and soluble proteins. The various FcγR (sub) classes of this family differ in ligand affinity and specificity, which is determined by primary structure, glycosylation, association with signaling subunits, and environmental factors (such as serine proteases). The finding that polymorphisms of FcγRIIa, FcγRIIIa, and FcγRIIIb critically affect interaction with antibodies has prompted analysis in patients which provided tantalizing evidence for the relevance of FcγR polymorphisms as risk factors for a number of infectious and autoimmune diseases.

Key words Fc receptor Polymorphism Autoimmune disorder Infectious disease Leukocyte 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • W.-Ludo van der Pol
    • 1
  • J. G. J. van de Winkel
    • 2
  1. 1.Department of Immunology, Utrecht University, G04.614, Heidelberglaan 100, 3584 CX Utrecht,The NetherlandsNL
  2. 2.Department of Immunology, and Medarex Europe, Medical School, Utrecht University, G04.614, Heidelberglaan 100, 3584 CX Utrecht, The NetherlandsNL

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