Immunogenetics

, Volume 47, Issue 1, pp 55–63

Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex

  • Rachid Tazi-Ahnini
  • Joëlle Henry
  • Claudine Offer
  • Catherine Bouissou-Bouchouata
  • Ian H. Mather
  • P. Pontarotti
ORIGINAL PAPER

DOI: 10.1007/s002510050326

Cite this article as:
Tazi-Ahnini, R., Henry, J., Offer, C. et al. Immunogenetics (1997) 47: 55. doi:10.1007/s002510050326

Abstract

 New members of the butyrophilin (BT) gene family have been identified by cDNA and genomic cloning. Six genes are described: BT2.1, 2.2, 2.3, and BT3.1, 3.2, and 3.3. BT2, BT3, and BT form three distinct subfamilies sharing about 95% amino acid identity at the intra subfamily level and 50% identity at the interfamily level. All the BT2 and BT3 subfamily members map close to BT in the juxta-telomeric region of the major histocompatibility complex. The BT2 members have the canonical structural organization of BT, i.e., two immunoglobulin domains followed by a transmembrane anchor and a B30.2 intracytoplasmic domain. In the BT3 subfamily, only BT3.3 has the structural organization of BT. The two other genes, BT3.1 and BT3.2, code for putative protein without the B30.2 domain. In the case of BT3.2, this is due to an Alu insertion in the B30.2 coding exon, leading to a new polyadenylation site.

Key words Evolution CD80/CD86 Hybrid sequences Alu element insertion Gene duplication 

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Rachid Tazi-Ahnini
    • 1
  • Joëlle Henry
    • 2
  • Claudine Offer
    • 1
  • Catherine Bouissou-Bouchouata
    • 1
  • Ian H. Mather
    • 3
  • P. Pontarotti
    • 4
  1. 1.UPR8291, CNRS, F-31300 Toulouse, FranceFR
  2. 2.ESR, CNRS, F-7071 Limoges, FranceFR
  3. 3.Department of Animal and Avian Sciences University of Maryland, College Park, MD 20742, USAUS
  4. 4.Unité INSERM 119, 27 Bd de lei roure, F-73009 Marseille, France e-mail: pontcaro.infobiogen.FrFR

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