Immunogenetics

, Volume 46, Issue 4, pp 307–311

The human natural killer gene complex is located on chromosome 12p12-p13

  • Mónica Renedo
  • Ignacio Arce
  • Antonio Rodríguez
  • Marta Carretero
  • Lewis L. Lanier
  • Miguel López-Botet
  • E. Fernández-Ruiz
ORIGINAL PAPER

Abstract

 Natural killer (NK) cells preferentially express several type II glycoproteins of the calcium-dependent lectin superfamily. The genes coding for these molecules are clustered on the distal mouse chromosome 6 and on the rat chromosome 4 in a region designated the NK gene complex. To date, no definite evidence of the presence of a NK gene complex has been found in humans. Here we report the assignment by fluorescence in situ hybridization of the CD94 gene to human chromosome 12p12-p13, in the same region where the CD69 and NKG2A genes had been previously mapped. In addition, using a yeast artificial chromosome contig spanning this region we determined that the human CD94, NKG2A, NKG2C, NKG2E, and NKR-P1A (NKR) genes map to the short arm of chromosome 12. The distal to proximal position of these loci are: NKR- CD69 - CD94/NKG2A/NKG2C/NKG2E. These data demonstrate the existence of a human NK gene complex located within a 5.6 cM interval flanked by the genetic markers D12S397 and D12S89. The physical distance spanned by the NK gene complex in humans ranges between 0.7 and 2.4 megabases.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Mónica Renedo
    • 1
  • Ignacio Arce
    • 1
  • Antonio Rodríguez
    • 2
  • Marta Carretero
    • 2
  • Lewis L. Lanier
    • 3
  • Miguel López-Botet
    • 2
  • E. Fernández-Ruiz
    • 1
  1. 1.Unidad de Biología Molecular, Hospital de la Princesa, Universidad Autónoma de Madrid, c/Diego de León 62, Madrid 28006, SpainES
  2. 2.Servicio de Inmunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, SpainES
  3. 3.Department of Human Immunology, DNAX Research Institute of Molecular and Cell Biology, Palo Alto, CA 94304, USAUS

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