Immunogenetics

, Volume 46, Issue 3, pp 226–230

Germline TCR-A restriction of immunoglobulin E responses to allergen

  • M. F. Moffatt
  • Carsten Schou
  • Jennie A. Faux
  • William O. C. M. Cookson
ORIGINAL PAPER

DOI: 10.1007/s002510050266

Cite this article as:
Moffatt, M., Schou, C., Faux, J. et al. Immunogenetics (1997) 46: 226. doi:10.1007/s002510050266

Abstract

 Immunoglobulin E responses to known environmental antigens (allergens) may serve as a general model to investigate germline genetic restriction of the immune response. We have previously shown genetic linkage between IgE responses to major allergens and the T-cell receptor (TCR) A/D locus, but not to TCR-B, implying that elements in TCR A/D restrict the ability to react to specific antigens. We now show, in two sets of subjects from the same population, a strong allelic association between a VA8.1 polymorphism (VA8.1*2) and reactivity to Der p II, a major antigenic component of the house dust mite Dermatophagoides pteronyssinus. Association was also seen between Der p II IgE titres and HLA-DRB1*1501 alleles. Reactivity to Der p II was confined to subjects who were positive for VA8.1*2 and HLA-DRB1*1501, demonstrating germline HLA-DR and TCR-A interaction in restricting the response to exogenous antigen.

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • M. F. Moffatt
    • 1
  • Carsten Schou
    • 2
  • Jennie A. Faux
    • 1
  • William O. C. M. Cookson
    • 1
  1. 1.Nuffield Department of Medicine, John Radcliffe Hospital, Oxford OX3 9DU, EnglandGB
  2. 2.ALK-ABELLO GROUP Research, Hørsholm, DenmarkDK

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