Immunogenetics

, Volume 51, Issue 2, pp 108–116

Nonlinkage of major histocompatibility complex class I and class II loci in bony fishes

  • A. Sato
  • F. Figueroa
  • B. W. Murray
  • E. Málaga-Trillo
  • Z. Zaleska-Rutczynska
  • H. Sültmann
  • S. Toyosawa
  • C. Wedekind
  • N. Steck
  • J. Klein
ORIGINAL PAPER

Abstract

 In tetrapods, the functional (classical) class I and class II B loci of the major histocompatibility complex (Mhc) are tightly linked in a single chromosomal region. In an earlier study, we demonstrated that in the zebrafish, Danio rerio, order Cypriniformes, the two classes are present on different chromosomes. Here, we show that the situation is similar in the stickleback, Gasterosteus aculeatus, order Gasterosteiformes, the common guppy, Poecilia reticulata, order Cyprinodontiformes, and the cichlid fish Oreochromis niloticus, order Perciformes. These data, together with unpublished results from other laboratories suggest that in all Euteleostei, the classical class I and class II B loci are in separate linkage groups, and that in at least some of these taxa, the class II loci are in two different groups. Since Euteleostei are at least as numerous as tetrapods, in approximately one-half of jawed vertebrates, the class I and class II regions are not linked.

Key words Gasterosteus aculeatus Poecilia reticulata Oreochromis niloticus Gene families Mhc organization 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • A. Sato
    • 1
  • F. Figueroa
    • 1
  • B. W. Murray
    • 1
  • E. Málaga-Trillo
    • 1
  • Z. Zaleska-Rutczynska
    • 1
  • H. Sültmann
    • 1
  • S. Toyosawa
    • 1
  • C. Wedekind
    • 4
  • N. Steck
    • 4
  • J. Klein
    • 1
  1. 1.Max-Planck-Institut für Biologie, Abteilung Immungenetik, Corrensstrasse 42, D-72076 Tübingen, Germany e-mail: jan.klein@tuebingen.mpg.de Tel.: +49-7071-601290 Fax: +49-7071-600437DE
  2. 2.Department of Biology, University of Konstanz, D-78457 Konstanz, GermanyDE
  3. 3.Department of Oral Pathology, Osaka University, Faculty of Dentistry, 1–8, Yamadaoka, Suita, Osaka 585-0871, JapanJP
  4. 4.Abteilung Verhaltensökologie, Zoologisches Institut, Universität Bern, SwitzerlandCH

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