Immunogenetics

, Volume 52, Issue 3–4, pp 206–211

Genomic structure, alternative splicing, and physical mapping of the killer cell lectin-like receptor G1 gene (KLRG1), the mouse homologue of MAFA

  • David Voehringer
  • Martina Kaufmann
  • Hanspeter Pircher
Original Paper

DOI: 10.1007/s002510000282

Cite this article as:
Voehringer, D., Kaufmann, M. & Pircher, H. Immunogenetics (2001) 52: 206. doi:10.1007/s002510000282

Abstract.

The mouse killer cell lectin-like receptor G1 (KLRG1), the mouse homologue of the mast cell function-associated antigen (MAFA), is an inhibitory C-type lectin expressed on natural killer (NK) cells and activated CD8 T cells. Here we report the complete nucleotide sequence, alternatively spliced variants, and the physical mapping of the KLRG1 gene in the mouse. The gene spans about 13 kb and consists of five exons. Short interspersed repeats of the B1 and B2 family, a LINE-1-like element, and a (CTT)170 triplet repeat were found in intron sequences. In contrast to human KLRG1 and to the murine KLR family members, mouse KLRG1 locates outside the NK complex on Chromosome 6 between the genes encoding CD9 and CD4.

C-type lectin KLRG1/MAFA Genomic sequence Physical mapping Alternative splicing 

Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  • David Voehringer
    • 1
  • Martina Kaufmann
    • 1
  • Hanspeter Pircher
    • 1
  1. 1.Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Hermann-Herderstr.11, 79104 Freiburg, Germany

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