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Update 2020: nomenclature and listing of celiac disease–relevant gluten epitopes recognized by CD4+ T cells

  • Ludvig M. SollidEmail author
  • Jason A. Tye-Din
  • Shuo-Wang Qiao
  • Robert P. Anderson
  • Carmen Gianfrani
  • Frits Koning
Review
  • 129 Downloads
Part of the following topical collections:
  1. Nomenclature, databases and bioinformatics in Immunogenetics

Abstract

Celiac disease is caused by an abnormal intestinal T cell response to cereal gluten proteins. The disease has a strong human leukocyte antigen (HLA) association, and CD4+ T cells recognizing gluten epitopes presented by disease-associated HLA-DQ allotypes are considered to be drivers of the disease. This paper provides an update of the currently known HLA-DQ restricted gluten T cell epitopes with their names and sequences.

Keywords

Celiac disease Gluten T cell Epitopes HLA-DQ2 HLA-DQ8 

Notes

References

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Ludvig M. Sollid
    • 1
    Email author
  • Jason A. Tye-Din
    • 2
  • Shuo-Wang Qiao
    • 1
  • Robert P. Anderson
    • 2
  • Carmen Gianfrani
    • 3
  • Frits Koning
    • 4
  1. 1.KG Jebsen Coeliac Disease Research Centre and Department of Immunology, Oslo University Hospital, RikshospitaletUniversity of OsloOsloNorway
  2. 2.Immunology DivisionThe Walter and Eliza Hall Institute of Medical ResearchParkvilleAustralia
  3. 3.Institute of Biochemistry and Cell BiologyNational Research Council of ItalyNaplesItaly
  4. 4.Department of Immunohematology and Blood TransfusionLeiden University Medical CenterLeidenThe Netherlands

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