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Immunogenetics

, Volume 71, Issue 1, pp 13–23 | Cite as

Limited MHC class II gene polymorphism in the West African chimpanzee is distributed maximally by haplotype diversity

  • Nel OttingEmail author
  • Natasja G. de Groot
  • Ronald E. Bontrop
Original Article

Abstract

Chimpanzees have been used for some time as an animal model in research on immune-related diseases in humans. The major histocompatibility complex (MHC) region of the chimpanzee has also been the subject of studies in which the attention was mainly on the class I genes. Although full-length sequence information is available on the DRB region genes, such detailed information is lacking for the other class II genes and, if present, is based mainly on exon 2 sequences. In the present study, full-length sequencing was performed on DQ, DP, and DRA genes in a cohort of 67 pedigreed animals, thereby allowing a thorough analysis of the MHC class II repertoire. The results demonstrate that the number of MHC class II lineages and alleles is relatively low, whereas haplotype diversity (combination of genes/alleles on a chromosome) seems to have been maximised by crossing-over processes.

Keywords

Chimpanzee MHC Nonhuman primates 

Notes

Acknowledgements

The authors wish to thank F. van Hassel for preparing the figures and D.M. Devine for editing this manuscript.

Supplementary material

251_2018_1080_MOESM1_ESM.docx (66 kb)
ESM 1 (DOCX 65 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Nel Otting
    • 1
    • 2
    Email author
  • Natasja G. de Groot
    • 1
    • 2
  • Ronald E. Bontrop
    • 1
    • 2
    • 3
  1. 1.Department of Comparative Genetics and RefinementBiomedical Primate Research CentreRijswijkThe Netherlands
  2. 2.IPD-MHC database Nonhuman Primate Nomenclature CommitteeRijswijkThe Netherlands
  3. 3.Department of Biology, Theoretical Biology and BioinformaticsUtrecht UniversityUtrechtThe Netherlands

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