Immunogenetics

, Volume 65, Issue 12, pp 897–900 | Cite as

Unique peptide-binding motif for Mamu-B*037:01: an MHC class I allele common to Indian and Chinese rhesus macaques

  • Natasja G. de Groot
  • Corrine M. C. Heijmans
  • Arnoud H. de Ru
  • Chopie Hassan
  • Nel Otting
  • Gaby G. M. Doxiadis
  • Frits Koning
  • Peter A. van Veelen
  • Ronald E. Bontrop
Brief Communication

Abstract

Indian and Chinese rhesus macaques are often used in biomedical research. Genetic analyses of the major histocompatibility class I region have revealed that these macaques display a substantial level of polymorphism at Mamu-A and Mamu-B loci, which have been subject to duplication. Only a few Mamu class I allotypes are characterised for their peptide-binding motifs, although more information of this nature would contribute to a better interpretation of T cell-mediated immune responses. Here, we present the results of the characterisation of the functional properties of Mamu-B*037:01, an allotype commonly encountered in rhesus macaques of Indian and Chinese origin. Mamu-B*037:01 is seen to have a strong preference for acidic amino acids at the third residue, and for arginine, lysine, and tyrosine at the carboxyl terminus. This peptide-binding motif is not described in the human population.

Keywords

Rhesus macaque HIV HLA MHC peptidomics Polymorphism Supertype 

Supplementary material

251_2013_734_MOESM1_ESM.pdf (269 kb)
Table S1List of 8-, 9-, 10-, and 11-mer eluted natural peptides with a mascot ion score of 35 or higher for Mamu-B*037:01. (PDF 269 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Natasja G. de Groot
    • 1
  • Corrine M. C. Heijmans
    • 1
  • Arnoud H. de Ru
    • 2
  • Chopie Hassan
    • 2
  • Nel Otting
    • 1
  • Gaby G. M. Doxiadis
    • 1
  • Frits Koning
    • 2
  • Peter A. van Veelen
    • 2
  • Ronald E. Bontrop
    • 1
    • 3
  1. 1.Comparative Genetics and RefinementBiomedical Primate Research CentreRijswijkThe Netherlands
  2. 2.Immunohaematology and Blood TransfusionLeiden University Medical CenterLeidenThe Netherlands
  3. 3.Theoretical Biology and BioinformaticsUtrecht UniversityUtrechtThe Netherlands

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