, Volume 64, Issue 8, pp 615–631 | Cite as

Nomenclature report on the major histocompatibility complex genes and alleles of Great Ape, Old and New World monkey species

  • Natasja G. de Groot
  • Nel Otting
  • James Robinson
  • Antoine Blancher
  • Bernard A. P. Lafont
  • Steven G. E. Marsh
  • David H. O’Connor
  • Takashi Shiina
  • Lutz Walter
  • David I. Watkins
  • Ronald E. Bontrop
Original Paper


The major histocompatibility complex (MHC) plays a central role in the adaptive immune response. The MHC region is characterised by a high gene density, and most of these genes display considerable polymorphism. Next to humans, non-human primates (NHP) are well studied for their MHC. The present nomenclature report provides the scientific community with the latest nomenclature guidelines/rules and current implemented nomenclature revisions for Great Ape, Old and New World monkey species. All the currently published MHC data for the different Great Ape, Old and New World monkey species are archived at the Immuno Polymorphism Database (IPD)-MHC NHP database. The curators of the IPD-MHC NHP database are, in addition, responsible for providing official designations for newly detected polymorphisms.


MHC NHP Database Nomenclature IPD 



The authors would like to thank D. Devine for editing the manuscript and H. van Westbroek for preparing the figures. This study was supported in part by NIH/NIAID contract numbers HHSN266200400088C, 5R24RR016038-05, and HHSN272201100013C. Bernard A.P. Lafont is supported by the intramural research program of NIAID-NIH.

Supplementary material

251_2012_617_MOESM1_ESM.pdf (55 kb)
Supplementary Table 1 Nomenclature table summarising the official and previous designations of rhesus, crab-eating, and southern pig-tailed macaques A alleles. The nomenclature tables for the macaque A alleles are available from the IPD-MHC NHP website. At the IPD-MHC NHP website the previous designation is listed in the column “Local Names”. (PDF 55 kb)
251_2012_617_MOESM2_ESM.pdf (64 kb)
Supplementary Table 2 Nomenclature table summarising the official and previous designations of rhesus, crab-eating, and southern pig-tailed macaques B alleles. The nomenclature tables for the macaque B alleles are available from the IPD-MHC NHP website. At the IPD-MHC NHP website the previous designation is listed in the column “Local Names”. (PDF 64 kb)


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Natasja G. de Groot
    • 1
  • Nel Otting
    • 1
  • James Robinson
    • 2
  • Antoine Blancher
    • 3
  • Bernard A. P. Lafont
    • 4
  • Steven G. E. Marsh
    • 2
    • 5
  • David H. O’Connor
    • 6
  • Takashi Shiina
    • 7
  • Lutz Walter
    • 8
  • David I. Watkins
    • 9
  • Ronald E. Bontrop
    • 1
    • 10
  1. 1.Department of Comparative Genetics and RefinementBiomedical Primate Research CentreRijswijkThe Netherlands
  2. 2.Anthony Nolan Research InstituteRoyal Free HospitalLondonUK
  3. 3.Laboratoire d’Immunogénétique moléculaire, EA 3034, Faculté de Médecine PurpanUniversité Paul SabatierToulouse 3France
  4. 4.Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA
  5. 5.UCL Cancer InstituteUniversity College London, Royal Free CampusLondonUK
  6. 6.Wisconsin National Primate Research CenterUniversity of Wisconsin-MadisonMadisonUSA
  7. 7.Department of Molecular Life Science, Division of Basic Medical Science and Molecular MedicineTokai University School of MedicineKanagawaJapan
  8. 8.Primate Genetics Laboratory, German Primate CenterLeibniz Institute for Primate ResearchGöttingenGermany
  9. 9.Department of PathologyUniversity of Miami School of MedicineMiamiUSA
  10. 10.Theoretical Biology and BioinformaticsUtrecht UniversityUtrechtThe Netherlands

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