Immunogenetics

, Volume 64, Issue 4, pp 261–265 | Cite as

Association of CISH -292A/T genetic variant with hepatitis B virus infection

  • Hoang V. Tong
  • Nguyen L. Toan
  • Le H. Song
  • Peter G. Kremsner
  • Jürgen F. J. Kun
  • Velavan TP
Original Paper

Abstract

Cytokine-inducible SRC homology 2 domain protein (CISH) is a suppressor of cytokine signaling that controls interleukin-2 signaling pathway. We investigated the single nucleotide polymorphism (SNP) -292A>T in 473 Vietnamese hepatitis B virus (HBV) carriers and 416 healthy controls. CISH variants at -292A>T were associated to HBV infection (Allelic: OR, 1.22 95% CI, 1–1.49; P = 0.04; Recessive: OR, 1.69 95% CI 1.23–2.54; P = 0.007). A gene dose effect for the risk allele -292T was observed (P = 0.04). The level of interleukin 2 and liver enzymes such as alanine transaminase, aspartate transaminase, total bilirubin, and direct bilirubin were not associated to CISH polymorphism at position -292A>T This study associated the vital role of CISH SNP -292A>T variant to hepatitis B virus infection in a Vietnamese population.

Keywords

CISH Gene variants Hepatitis B virus Genotype Alleles SNP 

References

  1. Excoffier L, Lischer HEL (2010) Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Mol Ecol Res 10:564–567CrossRefGoogle Scholar
  2. Guidotti LG, Guilhot S, Chisari FV (1994) Interleukin-2 and alpha/beta interferon down-regulate hepatitis B virus gene expression in vivo by tumor necrosis factor-dependent and -independent pathways. J Virol 68:1265–1270PubMedGoogle Scholar
  3. He YL, Zhao YR, Zhang SL, Lin SM (2006) Host susceptibility to persistent hepatitis B virus infection. World J Gastroenterol 12:4788–4793PubMedGoogle Scholar
  4. Jin P, Wang E, Provenzano M, Deola S, Selleri S, Ren J, Voiculescu S, Stroncek D, Panelli MC, Marincola FM (2006) Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsets. J Transl Med 4:26PubMedCrossRefGoogle Scholar
  5. Khor CC, Vannberg FO, Chapman SJ, Guo H, Wong SH, Walley AJ, Vukcevic D, Rautanen A, Mills TC, Chang KC, Kam KM, Crampin AC, Ngwira B, Leung CC, Tam CM, Chan CY, Sung JJ, Yew WW, Toh KY, Tay SK, Kwiatkowski D, Lienhardt C, Hien TT, Day NP, Peshu N, Marsh K, Maitland K, Scott JA, Williams TN, Berkley JA, Floyd S, Tang NL, Fine PE, Goh DL, Hill AV (2010) CISH and susceptibility to infectious diseases. N Engl J Med 362:2092–2101PubMedCrossRefGoogle Scholar
  6. Kovanen PE, Leonard WJ (2004) Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol Rev 202:67–83PubMedCrossRefGoogle Scholar
  7. Lavanchy D (2004) Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 11:97–107PubMedCrossRefGoogle Scholar
  8. Li S, Chen S, Xu X, Sundstedt A, Paulsson KM, Anderson P, Karlsson S, Sjogren HO, Wang P (2000) Cytokine-induced Src homology 2 protein (CIS) promotes T cell receptor-mediated proliferation and prolongs survival of activated T cells. J Exp Med 191:985–994PubMedCrossRefGoogle Scholar
  9. Lin SJ, Shu PY, Chang C, Ng AK, Hu CP (2003) IL-4 suppresses the expression and the replication of hepatitis B virus in the hepatocellular carcinoma cell line Hep3B. J Immunol 171:4708–4716PubMedGoogle Scholar
  10. Malek TR (2008) The biology of interleukin-2. Annu Rev Immunol 26:453–479PubMedCrossRefGoogle Scholar
  11. Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (1997) Cloning and characterization of novel CIS family genes. Biochem Biophys Res Commun 239:439–446PubMedCrossRefGoogle Scholar
  12. Matsumoto A, Masuhara M, Mitsui K, Yokouchi M, Ohtsubo M, Misawa H, Miyajima A, Yoshimura A (1997) CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood 89:3148–3154PubMedGoogle Scholar
  13. Nakajima Y, Tsuge I, Kondo Y, Komatsubara R, Hirata N, Kakami M, Kato M, Kurahashi H, Urisu A, Asano Y (2008) Up-regulated cytokine-inducible SH2-containing protein expression in allergen-stimulated T cells from hen's egg-allergic patients. Clin Exp Allergy 38:1499–1506PubMedCrossRefGoogle Scholar
  14. Nguyen VT, Law MG, Dore GJ (2008) An enormous hepatitis B virus-related liver disease burden projected in Vietnam by 2025. Liver Int 28:525–531PubMedCrossRefGoogle Scholar
  15. Singh R, Kaul R, Kaul A, Khan K (2007) A comparative review of HLA associations with hepatitis B and C viral infections across global populations. World J Gastroenterol 13:1770–1787PubMedGoogle Scholar
  16. Song IH, Binh VQ, Duy DN, Juliger S, Bock TC, Luty AJ, Kremsner PG, Kun JF (2003) Mannose-binding lectin gene polymorphisms and hepatitis B virus infection in Vietnamese patients. Mutat Res 522:119–125CrossRefGoogle Scholar
  17. Song IH, Toan NL, Xuan NT, Uhlemann AC, Boldt AB, Duy DN, Binh VQ, Kremsner PG, Kun JF (2006) A promoter polymorphism in the interferon alpha-2 gene is associated with the clinical presentation of hepatitis B. Mutat Res 601:137–143CrossRefGoogle Scholar
  18. Song IH, Xuan NT, Toan NL, Binh VQ, Boldt AB, Kremsner PG, Kun JF (2008) Association of two variants of the interferon-alpha receptor-1 gene with the presentation of hepatitis B virus infection. Eur Cytokine Netw 19:204–210Google Scholar
  19. Stoop JN, van der Molen RG, Baan CC, van der Laan LJ, Kuipers EJ, Kusters JG, Janssen HL (2005) Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology 41:771–778PubMedCrossRefGoogle Scholar
  20. Truelove AL, Oleksyk TK, Shrestha S, Thio CL, Goedert JJ, Donfield SM, Kirk GD, Thomas DL, O'Brien SJ, Smith MW (2008) Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome. Int J Immunogenet 35:255–264PubMedCrossRefGoogle Scholar
  21. Uchida K, Yoshimura A, Inazawa J, Yanagisawa K, Osada H, Masuda A, Saito T, Takahashi T, Miyajima A, Takahashi T (1997) Molecular cloning of CISH, chromosome assignment to 3p21.3, and analysis of expression in fetal and adult tissues. Cytogenet Cell Genet 78:209–212PubMedCrossRefGoogle Scholar
  22. Xu D, Fu J, Jin L, Zhang H, Zhou C, Zou Z, Zhao JM, Zhang B, Shi M, Ding X, Tang Z, Fu YX, Wang FS (2006) Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J Immunol 177:739–747PubMedGoogle Scholar
  23. Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A (1995) A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin-3 and erythropoietin receptors. EMBO J 14:2816–2826PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Hoang V. Tong
    • 1
  • Nguyen L. Toan
    • 2
  • Le H. Song
    • 3
  • Peter G. Kremsner
    • 1
  • Jürgen F. J. Kun
    • 1
  • Velavan TP
    • 1
  1. 1.Institute of Tropical MedicineUniversity of TübingenTübingenGermany
  2. 2.Department of PathophysiologyVietnam Military Medical UniversityHanoiVietnam
  3. 3.Tran Hung Dao HospitalHanoiVietnam

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