, Volume 64, Issue 4, pp 261–265 | Cite as

Association of CISH -292A/T genetic variant with hepatitis B virus infection

  • Hoang V. Tong
  • Nguyen L. Toan
  • Le H. Song
  • Peter G. Kremsner
  • Jürgen F. J. Kun
  • Velavan TP
Original Paper


Cytokine-inducible SRC homology 2 domain protein (CISH) is a suppressor of cytokine signaling that controls interleukin-2 signaling pathway. We investigated the single nucleotide polymorphism (SNP) -292A>T in 473 Vietnamese hepatitis B virus (HBV) carriers and 416 healthy controls. CISH variants at -292A>T were associated to HBV infection (Allelic: OR, 1.22 95% CI, 1–1.49; P = 0.04; Recessive: OR, 1.69 95% CI 1.23–2.54; P = 0.007). A gene dose effect for the risk allele -292T was observed (P = 0.04). The level of interleukin 2 and liver enzymes such as alanine transaminase, aspartate transaminase, total bilirubin, and direct bilirubin were not associated to CISH polymorphism at position -292A>T This study associated the vital role of CISH SNP -292A>T variant to hepatitis B virus infection in a Vietnamese population.


CISH Gene variants Hepatitis B virus Genotype Alleles SNP 


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Hoang V. Tong
    • 1
  • Nguyen L. Toan
    • 2
  • Le H. Song
    • 3
  • Peter G. Kremsner
    • 1
  • Jürgen F. J. Kun
    • 1
  • Velavan TP
    • 1
  1. 1.Institute of Tropical MedicineUniversity of TübingenTübingenGermany
  2. 2.Department of PathophysiologyVietnam Military Medical UniversityHanoiVietnam
  3. 3.Tran Hung Dao HospitalHanoiVietnam

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