, Volume 61, Issue 5, pp 327–339 | Cite as

Mhc haplotype H6 is associated with sustained control of SIVmac251 infection in Mauritian cynomolgus macaques

  • Edward T. MeeEmail author
  • Neil Berry
  • Claire Ham
  • Ulrike Sauermann
  • Maria T. Maggiorella
  • Frédéric Martinon
  • Ernst J. Verschoor
  • Jonathan L. Heeney
  • Roger Le Grand
  • Fausto Titti
  • Neil Almond
  • Nicola J. Rose
Original Paper


The restricted diversity of the major histocompatibility complex (MHC) of Mauritian cynomolgus macaques provides powerful opportunities for insight into host-viral interactions and cellular immune responses that restrict lentiviral infections. However, little is known about the effects of Mhc haplotypes on control of SIV in this species. Using microsatellite-based genotyping and allele-specific PCR, Mhc haplotypes were deduced for 35 macaques infected with the same stock of SIVmac251. Class I haplotype H6 was associated with a reduction in chronic phase viraemia (p = 0.0145) while a similar association was observed for H6 class II (p = 0.0063). An increase in chronic phase viraemia, albeit an insignificant trend, was observed in haplotype H5-positive animals. These results further emphasise the value of genetically defined populations of non-human primates in AIDS research and provide a foundation for detailed characterisation of MHC restricted cellular immune responses and the effects of host genetics on SIV replication in cynomolgus macaques.


Non-human primate Macaca fascicularis Genotype AIDS SIV 



We are grateful to the veterinary and support staff, and to Alan Heath for assistance with statistical analysis. This work was funded by the UK Department of Health; ENVEP, an EU Framework Programme 5 grant QLK2-CT-1999-00871; EUPRIM-NET, an EU Framework Programme 6 grant and Medical Research Council grant G9025730.

Supplementary material

251_2009_369_MOESM1_ESM.doc (40 kb)
Supplemental Table 1 Treatment regimens and infection outcome of animals included in study (DOC 39 kb)


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Edward T. Mee
    • 1
    Email author
  • Neil Berry
    • 1
  • Claire Ham
    • 1
  • Ulrike Sauermann
    • 2
  • Maria T. Maggiorella
    • 3
  • Frédéric Martinon
    • 4
    • 5
  • Ernst J. Verschoor
    • 6
  • Jonathan L. Heeney
    • 6
    • 7
  • Roger Le Grand
    • 4
    • 5
  • Fausto Titti
    • 3
  • Neil Almond
    • 1
  • Nicola J. Rose
    • 1
  1. 1.Division of RetrovirologyNational Institute for Biological Standards and ControlHertfordshireUK
  2. 2.German Primate Centre, Working Group Infection ModelsGöttingenGermany
  3. 3.Division of Experimental Retrovirology and Non-Human Primate Models, National AIDS CenterIstituto Superiore di SanitàRomeItaly
  4. 4.CEA, Division of Immuno-VirologyInstitute of Emerging Diseases and Innovative Therapies, DSVFontenay aux RosesFrance
  5. 5.Université Paris-SudOrsayFrance
  6. 6.Department of VirologyBiomedical Primate Research CentreRijswijkThe Netherlands
  7. 7.Department of Veterinary MedicineUniversity of CambridgeCambridgeUK

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