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Immunogenetics

, 60:339 | Cite as

MHC class I characterization of Indonesian cynomolgus macaques

  • Chad J. Pendley
  • Ericka A. Becker
  • Julie A. Karl
  • Alex J. Blasky
  • Roger W. Wiseman
  • Austin L. Hughes
  • Shelby L. O’Connor
  • David H. O’Connor
Original Paper

Abstract

Cynomolgus macaques (Macaca fascicularis) are quickly becoming a useful model for infectious disease and transplantation research. Even though cynomolgus macaques from different geographic regions are used for these studies, there has been limited characterization of full-length major histocompatibility complex (MHC) class I immunogenetics of distinct geographic populations. Here, we identified 48 MHC class I cDNA nucleotide sequences in eleven Indonesian cynomolgus macaques, including 41 novel Mafa-A and Mafa-B sequences. We found seven MHC class I sequences in Indonesian macaques that were identical to MHC class I sequences identified in Malaysian or Mauritian macaques. Sharing of nucleotide sequences between these geographically distinct populations is also consistent with the hypothesis that Indonesia was a source of the Mauritian macaque population. In addition, we found that the Indonesian cDNA sequence Mafa-B*7601 is identical throughout its peptide binding domain to Mamu-B*03, an allele that has been associated with control of Simian immunodeficiency virus (SIV) viremia in Indian rhesus macaques. Overall, a better understanding of the MHC class I alleles present in Indonesian cynomolgus macaques improves their value as a model for disease research, and it better defines the biogeography of cynomolgus macaques throughout Southeast Asia.

Keywords

MHC Immunogenetics Indonesia Macaca fascicularis 

Notes

Acknowledgements

This work was supported by 1 R24 RR021745-01A1. PCR-SSP assay development was supported by NIAID Contract number HHSN266200400088C/N01-AI-40088. Support to C.J.P. was made possible through funding for undergraduate research from the UW-Madison Hilldale Fund, and support to A.L.H. was provided by grant number GM43940 from the NIH. This publication was also made possible in part by grant number P51 RR000167 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), to the Wisconsin National Primate Research Center, University of Wisconsin—Madison. This research was conducted in part at a facility constructed with support from Research Facilities Improvement Program grant numbers RR15459-01 and RR020141-01. This publication’s contents are solely the responsibility of the authors and do not necessarily represent the official views of NCRR or NIH.

We thank the Washington Primate Research Center for providing blood samples from animals IN01 through 1N12 and the Cerus Corporation for providing PBMC from animals CE01 through CE30. We thank the MHC typing core at the Wisconsin Primate Research Center for typing the Indonesian cohort for Mamu-B*03. We acknowledge Natasja de Groot and the IMGT for assigning uniform allele nomenclature. Finally, we appreciate many members of the O’Connor lab for helpful discussions.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Chad J. Pendley
    • 1
  • Ericka A. Becker
    • 1
  • Julie A. Karl
    • 1
    • 2
  • Alex J. Blasky
    • 1
  • Roger W. Wiseman
    • 1
  • Austin L. Hughes
    • 3
  • Shelby L. O’Connor
    • 2
  • David H. O’Connor
    • 1
    • 2
    • 4
  1. 1.Wisconsin National Primate Research Center, University of Wisconsin—MadisonMadisonUSA
  2. 2.Department of Pathology and Laboratory MedicineUniversity of Wisconsin—MadisonMadisonUSA
  3. 3.Department of Biological SciencesUniversity of South CarolinaColumbiaUSA
  4. 4.University of Wisconsin—MadisonMadisonUSA

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