, Volume 60, Issue 3–4, pp 147–156 | Cite as

Evolution, expression and effectiveness in a cluster of novel bovine β-defensins

  • Paul Cormican
  • Kieran G. Meade
  • Sarah Cahalane
  • Fernando Narciandi
  • Aspinas Chapwanya
  • Andrew T. Lloyd
  • Cliona O’Farrelly
Original Paper


The anti-microbial peptides β-defensins constitute a large family of innate immune effector molecules, conserved across a wide species range. In this paper, we describe a systematic search of the sequenced bovine genome to characterise this extensive gene family in Bos taurus, providing an insight into the pattern of conservation of β-defensin genes between species. We have sequenced a sub-set of these newly discovered bovine β-defensin genes and also report expression data for these genes across a range of tissues. We have synthesised the peptide product of one of these genes, bovine β-defensin 123, and found it to be a potent inhibitor of several pathogenic microbes, particularly Escherichia coli and Listeria monocytogenes.


Anti-microbial peptide Defensin Bovine Bioinformatic 

Supplementary material

251_2007_269_MOESM1_ESM.txt (5 kb)
Supplementary materialsPeptide sequences for all β-defensins sequences coded for in the Bovine Genome Release 3.1 (TXT 5.03 KB)


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Paul Cormican
    • 1
  • Kieran G. Meade
    • 1
  • Sarah Cahalane
    • 1
  • Fernando Narciandi
    • 1
  • Aspinas Chapwanya
    • 1
  • Andrew T. Lloyd
    • 1
  • Cliona O’Farrelly
    • 1
  1. 1.School of Biochemistry and ImmunologyTrinity College DublinDublinIreland

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