The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL
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Homologues of almost all mammalian Ig-like immunoregulatory receptor families have been found in the chicken, except the Fc receptor (FcR) family. In addition to classical FcRs that specifically bind antibodies and mediate their effector functions, this family includes “Fc receptor-like” (FCRL) proteins for which ligands have yet to be identified. We have cloned and expressed a full-length chicken monocyte transcript that encodes an avian homologue of the mammalian FcR family. We have termed it chFcR/L as it possesses characteristics of both mammalian FcR and FCRL, but is phylogenetically distinct from either. chFcR/L is a transmembrane protein with four extracellular Ig-like domains and a short cytoplasmic tail. It can be expressed on the cell surface only in the presence of an accessory molecule, chFcRγ, through which it acquires signalling potential.
KeywordsChicken Avian Fc receptor Fc receptor homologue FcR FCRL
The authors would like to thank Ewan Birney and Cara Woodwark of the European Bioinformatics Institute, Cambridge, UK, for the advice on phylogenetic analysis. The MQ–NCSU cell line was provided by Dr. M. A. Qureshi, National Program Leader, Animal Genetics, USDA/Cooperative State Research, Education, and Extension Service, Washington, D.C., 20024, USA. This work is currently supported by a Biotechnology and Biological Sciences Research Council grant. Alex Taylor was previously supported by an MRC research studentship.
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