Evidence of positive selection on the Atlantic salmon CD3γδ gene
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Atlantic salmon are typically anadromous, spending the majority of their lifetime in oceans and returning to fresh water to breed. This diversity of environments likely results in strong selective forces shaping their genome. In this paper, we present the first genomics approach to detect positive selection operating on the Salmo salar (salmon) lineage, an important aquaculture species. We identify a panel of candidate genes that may have been subject to adaptive evolution in this species. In particular, we identify a robust signature of positive selection operating on the salmon CD3γδ gene, which encodes one of the protein chains essential for formation of the T-cell receptor complex and for T-cell activation. Furthermore, we identified the particular codon sites that have been subject to positive selection in fish and highlight two sites flanking an important N-glycosylation site in this molecule.
KeywordsAdaptive evolution Positive selection CD3γδ Glycosylation Salmon
This research was supported by a postdoctoral fellowship of Xunta de Galicia PGIDIT 2005 to Fernando Cruz. David J. Lynn is supported in part by Science Foundation Ireland grant no. 02-IN.1-B256. Thanks go to Professor Ken Wolfe, Smurfit Institute of Genetics, Trinity College, Dublin, for his helpful comments.
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