Immunogenetics

, Volume 58, Issue 5, pp 362–373

Ancient divergence of a complex family of immune-type receptor genes

  • John P. Cannon
  • Robert N. Haire
  • M. Gail Mueller
  • Ronda T. Litman
  • Donna D. Eason
  • Deborah Tinnemore
  • Chris T. Amemiya
  • Tatsuya Ota
  • Gary W. Litman
Original Paper

DOI: 10.1007/s00251-006-0112-7

Cite this article as:
Cannon, J.P., Haire, R.N., Mueller, M.G. et al. Immunogenetics (2006) 58: 362. doi:10.1007/s00251-006-0112-7

Abstract

Multigene families of activating/inhibitory receptors belonging to the immunoglobulin superfamily (IgSF) regulate immunological and other cell–cell interactions. A new family of such genes, termed modular domain immune-type receptors (MDIRs), has been identified in the clearnose skate (Rajaeglanteria), a phylogenetically ancient vertebrate. At least five different major forms of predicted MDIR proteins are comprised of four different subfamilies of IgSF ectodomains of the intermediate (I)- or C2-set. The predicted number of individual IgSF ectodomains in MDIRs varies from one to six. MDIR1 contains a positively charged transmembrane residue and MDIR2 and MDIR3 each possesses at least one immunoreceptor tyrosine-based inhibitory motif in their cytoplasmic regions. MDIR4 and MDIR5 lack characteristic activating/inhibitory signalling motifs. MDIRs are encoded in a particularly large and complex multigene family. MDIR domains exhibit distant sequence similarity to mammalian CMRF-35-like molecules, polymeric immunoglobulin receptors, triggering receptors expressed on myeloid cells (TREMs), TREM-like transcripts, NKp44 and FcR homologs, as well as to sequences identified in several different vertebrate genomes. Phylogenetic analyses suggest that MDIRs are representative members of an extended family of IgSF genes that diverged before or very early in evolution of the vertebrates and subsequently came to occupy multiple, fully independent distributions in the present day.

Keywords

Ig superfamily Evolution Activating/inhibitory signalling 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • John P. Cannon
    • 1
    • 2
  • Robert N. Haire
    • 1
    • 2
  • M. Gail Mueller
    • 3
  • Ronda T. Litman
    • 1
  • Donna D. Eason
    • 1
    • 2
  • Deborah Tinnemore
    • 4
  • Chris T. Amemiya
    • 4
  • Tatsuya Ota
    • 5
  • Gary W. Litman
    • 1
    • 2
    • 3
  1. 1.Department of PediatricsUniversity of South Florida College of Medicine, and USF/ACH Children’s Research InstituteSt. PetersburgUSA
  2. 2.Immunology ProgramH. Lee Moffitt Cancer Center and Research InstituteTampaUSA
  3. 3.Department of Molecular GeneticsAll Children’s HospitalSt. PetersburgUSA
  4. 4.Molecular Genetics ProgramBenaroya Research Institute at Virginia MasonSeattleUSA
  5. 5.Department of Biosystems Science and Hayama Center for Advanced StudiesThe Graduate University for Advanced Studies (Sokendai)HayamaJapan

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