Immunogenetics

, Volume 57, Issue 5, pp 326–336

The design and implementation of the immune epitope database and analysis resource

  • Bjoern Peters
  • John Sidney
  • Phil Bourne
  • Huynh-Hoa Bui
  • Soeren Buus
  • Grace Doh
  • Ward Fleri
  • Mitch Kronenberg
  • Ralph Kubo
  • Ole Lund
  • David Nemazee
  • Julia V. Ponomarenko
  • Muthu Sathiamurthy
  • Stephen P. Schoenberger
  • Scott Stewart
  • Pamela Surko
  • Scott Way
  • Steve Wilson
  • Alessandro Sette
Original Paper

DOI: 10.1007/s00251-005-0803-5

Cite this article as:
Peters, B., Sidney, J., Bourne, P. et al. Immunogenetics (2005) 57: 326. doi:10.1007/s00251-005-0803-5

Abstract

Epitopes are defined as parts of antigens interacting with receptors of the immune system. Knowledge about their intrinsic structure and how they affect the immune response is required to continue development of techniques that detect, monitor, and fight diseases. Their scientific importance is reflected in the vast amount of epitope-related information gathered, ranging from interactions between epitopes and major histocompatibility complex molecules determined by X-ray crystallography to clinical studies analyzing correlates of protection for epitope based vaccines. Our goal is to provide a central resource capable of capturing this information, allowing users to access and connect realms of knowledge that are currently separated and difficult to access. Here, we portray a new initiative, “The Immune Epitope Database and Analysis Resource.” We describe how we plan to capture, structure, and store this information, what query interfaces we will make available to the public, and what additional predictive and analytical tools we will provide.

Keywords

Epitope Antibody MHC Database 

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Bjoern Peters
    • 1
  • John Sidney
    • 1
  • Phil Bourne
    • 2
  • Huynh-Hoa Bui
    • 1
  • Soeren Buus
    • 3
  • Grace Doh
    • 4
  • Ward Fleri
    • 1
  • Mitch Kronenberg
    • 1
  • Ralph Kubo
    • 1
  • Ole Lund
    • 5
  • David Nemazee
    • 6
  • Julia V. Ponomarenko
    • 2
  • Muthu Sathiamurthy
    • 1
  • Stephen P. Schoenberger
    • 1
  • Scott Stewart
    • 7
  • Pamela Surko
    • 7
  • Scott Way
    • 7
  • Steve Wilson
    • 1
  • Alessandro Sette
    • 1
  1. 1.La Jolla Institute of Allergy and ImmunologySan DiegoUSA
  2. 2.San Diego Supercomputer CenterSan DiegoUSA
  3. 3.University of CopenhagenCopenhagenDenmark
  4. 4.SH Grace ConsultingSeoulSouth Korea
  5. 5.BioCentrum-DTUTechnical University of DenmarkLyngbyDenmark
  6. 6.Department of ImmunologyThe Scripps Research InstituteLa JollaUSA
  7. 7.Science Applications International CorporationSan DiegoUSA

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