Immunogenetics

, Volume 56, Issue 2, pp 107–110 | Cite as

CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans

  • Tara Stanton
  • Sally Boxall
  • Andrea Bennett
  • Pontiano Kaleebu
  • Christine Watera
  • Jimmy Whitworth
  • Neil French
  • Ritu Dawes
  • Adrian V. S. Hill
  • Walter Bodmer
  • Peter C. L. Beverley
  • Elma Z. Tchilian
Brief Communication

Abstract

The CD45 (leucocyte common) antigen is a haemopoietic cell specific tyrosine phosphatase essential for antigen receptor signalling in lymphocytes, and expression of different CD45 isoforms is associated with distinct functions. Here we describe a novel polymorphism in exon 4 (A54G) of the gene encoding CD45 (PTPRC) that results in an amino acid substitution of Thr-19 to Ala in exon 4. The 54G allele was identified in African Ugandan populations and was found with a suggestive but not statistically significant increase in frequency amongst HIV-seropositive Ugandans. This suggests that the 54G variant and CD45 splicing abnormalities might be associated with HIV infection.

Keywords

CD45 HIV Alternative splicing Polymorphisms Ugandan 

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Tara Stanton
    • 1
  • Sally Boxall
    • 2
  • Andrea Bennett
    • 2
  • Pontiano Kaleebu
    • 3
  • Christine Watera
    • 3
  • Jimmy Whitworth
    • 3
  • Neil French
    • 4
  • Ritu Dawes
    • 2
  • Adrian V. S. Hill
    • 5
  • Walter Bodmer
    • 1
  • Peter C. L. Beverley
    • 2
  • Elma Z. Tchilian
    • 2
  1. 1.Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, Cancer Research UKJohn Radcliffe HospitalOxford UK
  2. 2.The Edward Jenner Institute for Vaccine ResearchComptonUK
  3. 3.MRC Programme on AIDS in UgandaUganda Virus Research InstituteEntebbeUganda
  4. 4.Liverpool School of Tropical MedicineLiverpoolUK
  5. 5.Wellcome Trust Centre for Human GeneticsUniversity of OxfordOxford UK

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