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Linkage of Patr-AL to Patr-A and-B in the major histocompatibility complex of the common chimpanzee (Pan troglodytes)

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Abstract.

Patr-AL is a recently described gene found only in the common chimpanzee, but closely related in structure to the highly polymorphic Patr-A and HLA-A genes of the chimpanzee and human MHCs, respectively. Unlike Patr-A and HLA-A, the Patr-AL gene has little polymorphism and is not fixed in the chimpanzee genome. To determine whether Patr-AL is located in the MHC or elsewhere, we compared segregation of the Patr-AL gene with segregation of Patr-A and -B alleles in chimpanzee families. The results demonstrate that Patr-AL is an MHC class I gene present on different MHC haplotypes as defined by their combination of Patr-A and B alleles.

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Authors and Affiliations

  1. Departments of Structural Biology and Microbiology/Immunology, Stanford University School of Medicine, Stanford, CA 94305-5126, USA, , , , ,

    Ron Geller, Erin J. Adams, Lisbeth A. Guethlein & Peter Parham

  2. Tissue Typing Services, Anthony Nolan Bone Marrow Trust, The Royal Free Hospital, Pond Street, Hampstead London, NW3 2QG, UK, , , , ,

    Ann-Margaret Little & Alejandro J. Madrigal

Authors
  1. Ron Geller
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  2. Erin J. Adams
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  3. Lisbeth A. Guethlein
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  4. Ann-Margaret Little
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  5. Alejandro J. Madrigal
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  6. Peter Parham
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Geller, R., Adams, E.J., Guethlein, L.A. et al. Linkage of Patr-AL to Patr-A and-B in the major histocompatibility complex of the common chimpanzee (Pan troglodytes). Immunogenetics 54, 212–215 (2002). https://doi.org/10.1007/s00251-002-0452-x

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  • DOI: https://doi.org/10.1007/s00251-002-0452-x

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